Skin microbiome as a signature of premature ageing: enhancement with a retinyl propionate-containing topical product

作者：Yining Xu, Mingming Pu, Janhavi S. Raut, Yaping Du, Qiang Qiu, Kevin D. Hermanson, Ye Xu, Chandraprabha Doraiswamy, Chung-Ching Chu · 发表于：British Journal of Dermatology · 年份：2025 · DOI：10.1093/bjd/ljaf098 · 被引用次数：4 · 研究领域：Skin Protection and Aging、Dermatology and Skin Diseases、Acne and Rosacea Treatments and Effects

BACKGROUND: The perceived age and actual chronological age of a person can vary widely as a result of age-related features, such as wrinkles or hyperpigmented spots, that affect overall appearance. The perceived age of an individual can differ significantly from their chronological age, depending on environmental or lifestyle factors. While age-related changes of the skin microbiome have been characterized in healthy older and younger adults, the inter-relationship between the skin microbiome and the physiological appearance of ageing remains to be elucidated. OBJECTIVES: To compare the skin microbiome features of healthy adult women of similar chronological age (40-50 years old) exhibiting distinct premature and delayed ageing of the skin. METHODS: Participants exhibiting premature and delayed skin ageing were defined based on historical VISIA CR® images. Thirty volunteers with signs of premature ageing and 35 with delayed skin ageing were recruited. Participants with premature skin ageing were given a marketed product containing retinyl propionate to use twice daily for 4 weeks. Skin brightness, elasticity, hydration and barrier function were measured at baseline and 4 weeks after product use. Facial skin microbiome samples were collected from participants' upper cheeks using a cup scrub technique. Microbial DNA was extracted and sequenced at the variable region (V1-V2) of the 16S rDNA gene for bacterial classification and analysis. RESULTS: We found significant changes in ...