Transcutaneous Auricular Vagus Nerve Stimulation for Postpartum Contraction Pain During Elective Cesarean Delivery

作者：Xingyu Xiong, Mingshu Tao, Wenxin Zhao, Wen Tan, Yanyu Jiang, Zhengxiu Sun, Yuanyuan Wang, Yongao Lin, Chunyan Li, Jie Yang, Yuan Han, Hongxing Zhang, Song Zhang, He Liu, Jun‐Li Cao · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.29127 · 被引用次数：15 · 研究领域：Pediatric Pain Management Techniques、Vagus Nerve Stimulation Research、Pain Management and Treatment

Importance: Postpartum uterine contraction pain manifests as a severe, intermittent lower abdominal discomfort caused by uterine contraction during the early puerperium. Transcutaneous auricular vagus nerve stimulation (taVNS) has demonstrated promising effects in managing both acute and chronic pain conditions; however, there remains a paucity of studies regarding the use of taVNS for alleviating postpartum uterine contraction pain. Objective: To investigate the effect of taVNS in alleviating postpartum uterine contraction pain among women receiving combined spinal-epidural anesthesia for elective cesarean delivery. Design, Setting, and Participants: This randomized clinical trial was conducted from April 6 to August 31, 2024, at the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. Participants were aged 18 years or older and scheduled for elective cesarean delivery. Statistical analysis was performed in September 2024. All analyses were conducted according to the intention-to-treat principle. Interventions: Participants were randomly allocated 1:1 to either the active taVNS group or the sham taVNS group. Both groups received the stimulation for 30 minutes each time, once a day, on the day of surgery and postoperative days 1 and 2. Main Outcomes and Measures: The primary outcome was the incidence of moderate to severe postpartum uterine contraction pain on the third postoperative day, evaluated using a visual analogue scale (uterine contraction pain was class...