Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells

作者：Yan-Ruide Li, Junhui Hu, Zhe Li, Enbo Zhu, Yuning Chen, Tyler Halladay, Xinyuan Shen, Ying Fang, Yichen Zhu, Zibai Lyu, Yanxin Tian, Jie Huang, Aiqi Zhao, Y Nathan, Catherine Zhang, Yongpeng Xie, Hanwei Zhang, Tzung K. Hsiai, Arnold I. Chin, Lily Wu, Lili Yang · 发表于：Cell Reports Medicine · 年份：2025 · DOI：10.1016/j.xcrm.2025.102321 · 被引用次数：15 · 研究领域：CAR-T cell therapy research、Immune Cell Function and Interaction

Li et al. generate allogeneic CD70-directed CAR-engineered NKT (AlloCAR70-NKT) cells from hematopoietic stem and progenitor cells using a clinically guided culture method. These cells exhibit multimodal targeting of renal cell carcinoma (RCC) tumor cells, the tumor microenvironment, and alloreactive T cells, representing a promising approach for metastatic RCC therapy.