Engineering Bacteria as Living Therapeutics in Cancer Therapy

作者：Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai · 发表于：Advanced Science · 年份：2025 · DOI：10.1002/advs.202507820 · 被引用次数：11 · 研究领域：Cancer Research and Treatments、3D Printing in Biomedical Research、Nanoplatforms for cancer theranostics

Cancer is the second-leading cause of death globally, yet traditional therapies like chemotherapy face significant limitations. Recent advances in synthetic biology enable the design of various genetic circuits and the reprogramming of biological systems. Collectively, these efforts have led to the repurposing of engineered bacteria as therapeutics to achieve tumor targeting, tumor microenvironment modulation, and anticancer drug release. Here, these recent efforts are reviewed and discussed the challenges and future opportunities.