Treatments of depressive symptoms in cancer patients: A systematic review and network meta-analysis

作者：Wenhai Fu, Yuexin Liu, Yu Jiang, Hongjiang Chu, Robin Shao, Peiling Chen, Xin Zheng, Caichen Li, Jianxing He, Kangguang Lin, Wenhua Liang · 发表于：Translational Psychiatry · 年份：2025 · DOI：10.1038/s41398-025-03507-z · 被引用次数：4 · 研究领域：Childhood Cancer Survivors' Quality of Life、Cancer survivorship and care、Pediatric Pain Management Techniques

BACKGROUND: Depression is are often insufficiently managed in cancer patients globally. To address this, we conducted a comprehensive systematic review and network meta-analysis to evaluate and compare the effectiveness of pharmacological and non-pharmacological interventions in alleviating depressive symptoms in adult cancer patients. METHODS: We searched PubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov from inception until 31 July 2024, with an updated search conducted on 10 January 2025. Eligible studies were randomised controlled trials evaluating pharmacological or non-pharmacological interventions for depressive symptoms in adult patients with cancer (aged ≥18 years). Studies involving paediatric populations, lacking complete outcome data, or not reporting intervention outcomes were excluded. A Bayesian network meta-analysis was undertaken to compare the effectiveness of included interventions. The review protocol was prospectively registered in PROSPERO (CRD42023465056). FINDINGS: A total of 95 RCTs involving 17,260 participants were included. Several non-pharmacological interventions indicated potential benefit compared with usual care, notably massage and touch therapy (standardised mean difference [SMD]: -0.76, 95% CI: -1.37 to -0.16; low certainty), relaxation therapy (SMD: -0.59, 95% CI: -1.06 to -0.11; low certainty), psychotherapy (SMD: -0.43, 95% CI: -0.56 to -0.30; low certainty), and education and support of person with cancer (SMD: -0.30, 95% CI:...