The differential gut microbiota and their MetaCyc pathways in IBRV infected Angus calves

作者：Pengfei Yi, Tianqing Li, Liping Xu, Xin Li, Haiyan Wang, Yingcai Ma, Yunxiao Ma, Yawei Sun, Na Li, Qi Zhong, Xuelian Ma, Gang Yao · 发表于：Frontiers in Microbiology · 年份：2025 · DOI：10.3389/fmicb.2025.1588341 · 被引用次数：1 · 研究领域：Mycobacterium research and diagnosis、Gut microbiota and health、Clostridium difficile and Clostridium perfringens research

Infectious bovine rhinotracheitis virus (IBRV) is a globally prevalent pathogen that causes respiratory disease in cattle. Emerging evidence suggests that specific bacterial taxa and gut microbial community compositions are strongly associated with viral pathogenesis, by either enhancing or mitigating disease outcomes. This not only impacts the host’s gastrointestinal physiology but also affects distant organs, including the lungs, liver, and brain. However, the impact of IBRV infection on changes in gut microbiota composition and its association with MetaCyc metabolic pathways remains poorly understood. In this study, based on an epidemiological survey of one-month-old Angus calves in a large-scale Angus beef cattle breeding farm consists of four breeding areas located in Maigaiti County of Kashi Prefecture, China. Alterations in the gut microbiota of 10 IBRV-infected Angus calves (IBRV-positive group, P) compared with their 10 healthy counterparts (IBRV-negative group, N), as well as their correlations with MetaCyc metabolic pathways, were investigated using 16S rRNA sequencing. In comparison with N, both Simpson, Shannon and Pielou_e indices of alpha diversity were elevated in P, and the beta diversity showed a marked separation between N and P. The relative abundance of phylum Firmicutes_C was significantly increased, whereas that of phyla Bacteroidota, Cyanobacteria, and Firmicutes_D were reduced in P. The relative abundance of Genera Dialister and Klebsiella were enrich...