Exploring the mediating role of serum vitamin D in the link between dietary live microbes intake and obesity: a cross-sectional real-world study

作者：Chan Liu, Huiling Zheng, Wenming Xu, Xiaoxiao Zhu, Li Mei, Lijuan Liu · 发表于：Frontiers in Nutrition · 年份：2025 · DOI：10.3389/fnut.2025.1588700 · 被引用次数：3 · 研究领域：Vitamin D Research Studies、Gut microbiota and health、Nutrition, Genetics, and Disease

Background Existing research results suggest a correlation between body mass index (BMI) and serum vitamin D levels, as well as the intake of live microbes from dietary sources. However, it is essential to further investigate whether serum vitamin D could serve as a mediator in the relationship between the consumption of dietary live microbes and obesity, as this connection remains to be elucidated. Methods We analyzed data from 18,099 participants in the 2007–2018 National Health and Nutrition Examination Survey (NHANES), focusing on obesity [assessed via BMI and waist circumference (WC)], serum vitamin D levels, and the dietary intake of live microbes (evaluated both as a continuous variable and a three-level categorical variable). A composite category “MedHi” was used to reflect the intake of foods containing medium (10 4 –10 7 colony-forming units (CFU/g)) or high (>10 7 CFU/g) levels of live microbes. Mediation analysis was conducted to explore how serum vitamin D potentially mediates the relationship between the dietary intake of live microbes and obesity. Results After adjusting for potential confounding factors, it was found that both vitamin D and the MedHi consumption were strongly and negatively associated with obesity. Mediation analysis revealed that serum vitamin D mediated the relationship between the dietary intake of live microbes and BMI, WC, obesity, and abdominal obesity with mediated proportions of 14.6, 12.5, 13.0, and 12.5%, respectively. Conclus...