Surgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 study

作者：Xin Hu, Menglu Ouyang, Jianguo Xu, Yi Liu, Xi Li, Yan Jiang, Xiaoying Chen, Laurent Billot, Qiang Li MBiostat, Alejandra Malavera, Paula Muñoz Venturelli, Asita de Silva, Nguyen Huy Thang, Kolawole Wahab, Jeyaraj Pandian, Mohammad Wasay, Octávio Marques Pontes‐Neto, Carlos Abanto, Antonio Araúz, Zongping Li, Minhui Chen, Xiaofeng Wang, Chengyi Yang, Xiaodong Xin, Dehua Jiang, Jun Zheng, Zhiyuan Yu, Anqi Xiao, Chuanyuan Tao, Lei Chen, Bo Wu, Hao Li, Craig S. Anderson, Chao You, Lili Song, Lili Song, Lu Ma, Lu Ma, Octávio Marques Pontes‐Neto, Millene Rodrigues Camilo, Francisco Antunes Dias, Octavio Vincenzi, Rodrigo Cerantola, Carla Heloísa Cabral Moro, Renata Santos, Nara Texeira, Alexandre Luiz Longo, R. Liberato, Sheila Cristina Ouriques Martins, Arthur Pille, Bruna Cristine Chwal, Isabel Silva, N.F. Titton, Gustavo Weiss, Daissy Mora, Magda Ouriques, Leonardo Augusto Carbonera, Rodrigo Bazán, Gabriel Pinheiro Módolo, Fernanda Cristina Winckler, Luana Miranda, Juli Thomaz de Souza, Alexis Rojo, Wilhelm Uslar, Lorena Medel, Paula Munoz Venturelli, Javiera López, D. Herrero, Pablo M. Lavados, Barbara Vargas Latorre, Nathalie Conejan, Tomas Esparza, Patricio Sotomayor, Denisse Wenger, Juan Pablo Gigoux, Aldo Letelier, Lilian Acevedo, Vivianne Moya, Cristian Figueroa, N. Vallejos, Nathalie Conejan, Tomas Esparza, Patricio Sotomayor, Rodrigo Guerrero, Mauricio Velásquez, José Vallejos, Kimerly Pallauta, Tamara Santibanez, Angelo Queirolo, A.-T. Lobos, Aralikatte Onkarappa Saroja, Ravishankar Naik k, Sandip Chindhi, Nakul Pampaniya, Kurubara Amaresh, Thomas Iype, R Dileep, Reeja Rajan, Praveen Panicker, Rupjyoti Das, Nupur Choudhury, P. Gohain, Jemin Webster, Biyol Pakma, Lalbiak Sangi, Ivy Sebastian, Gaurav Aggrawal, Komal Raj, Deepankshi Rajoura, Sulena Singh, Varun Aggrawal, Amit Narang, Antonio Arauz, Vanesa Cano-Nigenda, Diego Là pez-Mena, Héctor Valdez-Ruvalcaba, Roberto Toledo-Treviño, Reginald Obiako, Sani Abubakar, Oguike Emeka, Olayemi Balogun, Melika Lois, Ibinaiye Philip, Olurishe Comfort O, Njideka Okubadejo, Osigwe Agabi, Oluwadamilola O. Ojo, Kolawole Wahab, Abiodun Bello, Oyinloye Ibukun, Olufemi Sanayaolu, Sunday Adeniyi, Abdulraheem Jimoh, Mohammad Wasay, Dilshad Begum, Anila Anjum, Shahid Waheed, Ayeesha Kamran Kamal, Raja Farhat Shoaib, Fizza Orooj, Sadaf Majid, Taskeen Zehra, Abdus Salam Khan, Ravi Shanker, Nadir Ali Syed, Nashwa Ahmad, Carlos Abanto, Ana P. Valencia, Danny M. Barrientos-Imán, Jorge Ramirez, Pilar Fernández–Calle, Dilum Palliyeguruge, Sumudu Muthucumarana, Shiroma Ratnayaka, Dilhara Ganihiarachchi, Arundathi Bandaranayake, Seneviratnage Somaratne, Saumya Narayana, Sithara Gallage, Bimsara Senanayake, Udari Samarasiri, Dunya Luke, Mythily Sivapathasundaram, Vithoosan Sahadevan, Amani Rasmi, Yuran Deshaka, Nilukshi Fernando, Aruna Munasinghe, Kapilanga Rathnapriya, A.S Nissanka, K. T. G. S. Karunathilake, Isuru Gayan, Kaminda Wijenayake, H.D.D.C. Gunasekara, Jagath Vidyarathne, Ajantha Keshavaraj, Kanagasabapathy Janarthanan, Arhivalaky Gerald Jeevathasan, Sivaram Sivamainthan, Mathyamuthan John Priyanth, Abirami John Priyanth, Thambippillai Rajendiran, Sanjeewa Alwis, Nushara Gunasekare, Vasundara Liyanarachchi, Athula Dissanayake, W. Uluwattage, G. Ratnayake, Charika Rajinee, S. Jayawardana, J B Peiris, Ranjith Wicramasinghe, Chamila Fernando, Jessie Abbas, Nethmini Withanage, Makaranda Bandara, Duy Ton Mai, Van Chi Nguyen, Viet Phương Đào, Xuan Trung Vuong, Tien Dung Nguyen, Trung Hieu Dinh, Ha Quan Phan, Q. Bui, Dinh Tho Phung, Quang Pham, Dinh Dai Pham, Duc Thuan Do, Dang Hai Nguyen, Minh Duc Dang, Dang Hai Nguyen, Thi Phuong Nga Nguyen, Quoc Huy Nguyen, Quoc Dai Pham, Quoc Vinh Chau, Vinh Thy Van Tai, Tran Vinh Le, Cong Tri Le, Ha Mai Khuong Tran, Huu Khanh Nguyen, Hoang Minh Thao Ngyen, Duc Chien Vo, Thai My Phuong Nguyen, Trung Thanh Tran, Thi Hanh Vi Vo, Hao Nhien Cao, Ba Thang Nguyen, T. Le, Thien Duc La, Chi Duc Pham, Huy Thai, Yongming Jiang, Weimin Li, Wei Huang, Ke Luo, Gangying Liu, Guanghai Tang, Guang Yang, Hongtao Jiang, Xu Zhang, Hongyan Jing, Sheng Zhu, Bo Pu, Dong Lv, Hui Kang, Qiuping Hu, Xiaochun She, Xiaoming Jiang, Yanli Chen, Shenghua Yang, Jianjun He, Zongping Li, Gang Cheng, Hailin Huang, Xiaoyi Wang, Jianqiong Lin, Minhui Chen, Chenghao Yang, Hao Ding, Yunliang Deng, Fei Luo, Rongjun Zhang, Xiaoliang Yang, Hongbing Zhang, Xiaoliang Yang, Yang Zhang, Chengyi Yang, Yu He, Feng Liu, Rongjie Wang, Yuhui Zhang, Xiaodong Xin, Bin Feng, Wanru Hao, Chang Eun Song, Yun Guo, Dehua Jiang, Jie Chen, Changtong Tang, Hongliang Zhu, Xin Li, Jin Cui, Haidong Xu, Boyang Li, Fusheng Tang, Yuanbin Li, Min Gao, Bo Yang, Xuejun Xu, Bing Deng, Yi Zheng, Yuanhong Ge, Keyu Chen, Yang Liu, Xinshen Li, Tingting Zhong, Jianfeng Xu, Hai Zhang, Jiyue Wang, Jian‐Xin Zhu, Hanyu Sun, YU Fu-hua, Xueguang Zhang, Chao You, Lu Ma, Lu Ma, Xin Hu, Jianguo Xu, Xi Li, Zhang Mingsen, Bin Wang, Yiming Ma, Donglin Jiang, Jun Zhou, Cong Liu, Wenhong Nie, Mingguo Li, Tao Tian, Yong Li, Mingfang He, Xiaolong Tu, Zhengjun Wu, Hong Liu, Dongsheng Zhong, Rongcai Jiang, Jian Sun, Ye Tian, Yingsheng Wei, Shuo An, Pingbo Wei, Le Luo, Bin Lin, Gang Liu, Yan Wen, Qiang Cai, Qianxue Chen, Pan Lei, Zhiyang Li, Meifang Zhang, Jiaquan He, Yan Chen, Jun Liu, Xing‐Hai Liu, Junyan Li, Min Chen, Jing Wang, Bingzhi Zhou, Baichun Ye, Jiancheng Zhang, Manyuan Zhang, Xuming Pan, Xiaoxiang Yu, Jian Xu, Qingbao Xiao, Yuefei Wang, Tao Liang, Lin Shi, Niandong Zheng, Guoliang You, Bo Lei, Shu Chen, Honggang Wu, Hu Jin, Jian‐Lan Zhao, Jian Yu, Qiang Yuan, Zhuoying Du, Xielin Tang, Qianke Li, Shenghua Liu, Feilong Yang, Kui Xiao, Chao Luo, Guang Wang, Xudong Che, Zhipeng Teng, Wenwu Wan, Jun Li, Yu Liu, Mingbo Fan, Tao Zhang, Lun Cai, Yuan Ma, Zhifeng Ma, Bin Li, Linlin He, Jinghui Li, Weibing Zhang, Shuxin Zhang, Hongzhen Zhang, Yingguang Dai, Jun Lei, Lei Mao, Yiyang Huang, Zhiguang Zhou, Ping Chen, Fang Chen, Pan Wei, Tiangui Li, Honglin Chen, Mengfei Zeng, Kejie Mou, Jun Xue, Yong Jiang, Xiaoping Tang, Tao Chen, Yalan Zhang, Yanbing Xu, Yuchen Gu, Lei Chen, Yu‐Jun Zhao, Bin Yang, Peng Kuai, Xi Wang, Yintao Yang, Xueling Hu, Huitian Zhang, Yintao Yang, Weifeng Wang, Junyi Zhang, Wei Cheng, Xiaoxue Zhang, Xiaowen Ma, Qin He, Li Zhang, Rong Gao, Huixiang Liu, Jingwei Ye, Ping Xu, Xin Wu, Yuan Yuan, Peng Zou, Zhen Zhang, Jiyong Cheng, Zhangming Zhou, Yijun Zeng, Liang Zhang, Deming Du, Shui Yu, Yongjun Cao, Shoujiang You, Jiaping Xu, Zhichao Huang, Dongqin Chen, Wenfeng Xiao, Li Zhu, Yuan Miao, Yuhai Wang, Dongliang Shi, Xu Hu, Dingchao Xiang, Like Shi, Hong‐Qin Wang, Liu Yang, Miao Wang, Yiyi Hu, Yuchun Zhao, Xi Hu, Yang Liu, Weiduo Zhou, Chao Sun, Tao Chen, Dong Tang, Kun Yao, Jin Jong You, Shishi Chen, Jian-min Yao, Huanmei Li, Jinmei Liu, Ailin Bai, Yong Yi, Qingshan Deng, Peng Luo, Han Wang, Jingcheng Jiang, Qingwei Yang, Shunpo He, Jun Wang, Yu Chen, Hua He, Yuyang Deng, Zhikai Cao, Xuxia Yi, Jinbiao Luo, Shuang Luo, Min Gong, Li Liu, Xuejun Gao, Jia Liu, Lie Wu, Jia Zhang, Hongying Sun, Xinhui Li, Jia Lu, Jianbing Wu, Jie Zhang, Huajun Zhang, Chunfu Du, Shun Li, Xiaobin Yang, Jie He, Lei Liao, Gezhi Zhou, Wentao Dong, Yunxiang Chen, Xiaofeng Lin, Xujian Shui, Peng Zhang, Yuan Zhao, Hongli Yang, Wenbin Zhao, Xiaoyi Zhang, Jincao Chen, Qian Wu, Xuan Dai, Baogui Tang, Yinjuan Wang, Tao Liu, Haixia Zhang, Faliang Duan, Ming Luo, Qing-fang Jiao, Guoliang Lei, Dong Wang, Chunwang Song, Haopeng Tan, Feng Ye, Xinghu Qin, Xiaolong Liang, J. Liu, Lang Yang, Jie Yang, Yapeng Lin, Qian Yang, Xuntai Ma, Yinkuang Qi, Baogen Pan, Caixia Jiang, Zhanying Ye, Ce Dong, Xiongfei Yue, Xiaopeng Yang, Tuoheti Maimaitiyiming, Jun Dong, Wu Yonggang, Feng Gao, Deqiang Zhao, Xinghai Zhang, PengJun Wang, Hongbo Jiang, Jianping Li, Wei Zhang, Jing Chen, Haibo Tong, Yonghong Wang, Kaipeng Qiao, Fuyou Guo, Mingchu Zhang, Yan Hu, Mengzhao Feng, Dengpan Song, Yi Zuo, Shangjun Chen, Chao Qian, Baoming Li, Jingku Ma, Sunfu Zhang, Bin Kong, Xingyu Dong, Yang Li, Sheng Fang, Bin Lu, Yang Li, Zhen Zhang, Yongling Yang, Yu Hong, Huaiyu Sun, Yue Wang, Weimin Wang, Tong Li, Shengli Li, Zhiming Xu, Yongyi Wang, Qiang Dong, Yuping Tang, Heling Chu, Ying Lu, Zhong Wang, Xiaoou Sun, Jianhua Zhao, Shuaifeng Yang, Xiying Qian, Thompson Robinson, J. Jaime Miranda, Craig S. Anderson, Chao You, Lili Song, Lili Song, Adrian Parry‐Jones, Nikola Sprigg, S. F. Durrans, Caroline Harris, Ann Bamford, Olivia Smith, Robert J. Herbert, Christopher Chen, William Whiteley, Rong Hu, Laurent Billot, Feifeng Liu, Jayanthi Mysore, Xin Hu, Yao Zhang, Feifeng Liu, Yuki Sakamoto, Shoujiang You, Qiao Han, Bernard Crutzen, Yunke Li, Emily Cheung, Stephen Jan, Hueiming Liu, Menglu Ouyang, Lingli Sun, Honglin Chu, Anila Anjum, Francisca Gonzalez Mc Cawley, Yan Wu, Lingling Feng, NI Jing-jing, Caixiu Du, Weiwei Fu, Alejandra Del Río, Bruna Rimoli, Rodrigo Cerantola, Thanushanthan Jeevarajah, Madhushani Kannangara, Andrene Joseph, Chamath Nanayakkara, Xiaoying Chen, Alejandra Malavera, Chunmiao Zhang, Zhao Yang, Brook Li, Zhuo Meng, Menglu Ouyang, Leibo Liu, Yi Ning, Le Dong, Manuela Armenis, Joyce Lim, Helen Monaghan, Lu Ma, Lu Ma, Xin Hu, Xi Li, Rui Luo, Guojuan Cheng, Yilin Dong, Ziqin Liu, Shuihong Wang, Ying Zhang, J.P. Cheng, Hui Shi, Wenjing Li, Langming Mou, Ping Yi, Chen Chen, X Chen, Shalomi Weerawardena, Poornima Ellawala, Enalee Ranasinghe, Chrishmi Rodrigo, Kolawala Wahab, Sunday Adeniyi, Jeyaraj Pandian, Megha Khanna, Paula Muñoz Venturelli, Francisca González, Francisca Urrutia Goldsack, A.D. Rao, Mohammad Wasay, Dilshad Begum, Anila Anjum · 发表于：The Lancet Regional Health - Western Pacific · 年份：2025 · DOI：10.1016/j.lanwpc.2025.101669 · 被引用次数：2 · 研究领域：Intracerebral and Subarachnoid Hemorrhage Research、Traumatic Brain Injury and Neurovascular Disturbances、Intracranial Aneurysms: Treatment and Complications

Background: There is ongoing controversy as to whether surgical intervention to haematoma evacuation benefits patients with acute intracerebral haemorrhage (ICH). This study aimed to evaluate the association of surgical intervention to evacuate the haematoma and 6-month functional outcome in participants of the third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3). Methods: This was a secondary analysis of INTERACT3, which enrolled adults (age ≥18 years) spontaneous ICH patients within 6 h after onset. INTERACT3 was an international, multicentre, prospective, stepped-wedge, cluster randomised, blinded outcome assessed, clinical trial undertaken at 121 hospitals in 10 countries between December 12, 2017 and December 31, 2021. To limit heterogeneity in the results, we restricted analyses to participants in China. The primary outcome was poor functional outcome, defined by a score of 5-6 on the modified Rankin scale (mRS), at 6 months. Secondary outcomes include a mRS score of 4-6 and mortality at 6 months. Sensitivity analysis included propensity score matched analysis and the imputation of missing outcome variables. The effect of timing on surgical outcome was also evaluated. The INTERACT3 trial was registered at ClinicalTrials.gov (NCT03209258) and CHiCTR.org.cn (ChiCTR-IOC-17011787). Findings: Of 5772 participants (mean age 62.0 ± 12.5 years) at 82 sites in China, 1411 (24.4%) received surgery in which craniotomy (72.6%) wa...