Comparison of the efficacy of single vs. double autologous platelet-rich plasma intrauterine infusion on endometrial receptivity in thin endometrium patients: a prospective randomized controlled trial

作者：Keng Feng, Lingling Zhu, Yudi Luo, Luhai Ruan, Derong Li, Xiang Li, Lei Li, Ling Wu · 发表于：Frontiers in Endocrinology · 年份：2025 · DOI：10.3389/fendo.2025.1609556 · 被引用次数：4 · 研究领域：Ovarian function and disorders、Gynecological conditions and treatments、Sexual function and dysfunction studies

Objective: To compare single versus double autologous platelet-rich plasma (PRP) intrauterine infusion effects on endometrial receptivity and pregnancy outcomes in patients with thin endometrium. Methods: This randomized controlled trial included 100 patients with thin endometrium and infertility, assigned to single (n=50) or double (n=50) infusion groups. The single group received 1.0 ml of PRP on day 11 of the hormone replacement therapy-frozen embryo transfer (HRT-FET) cycle, while the double group received 1.0 ml on both days 11 and 13. Primary outcomes included endometrial thickness, receptivity changes, and clinical pregnancy rates; secondary outcomes were cycle cancellation rate, miscarriage rate, and endometrial hemodynamics. Statistical analysis was conducted using SPSS 26.0. Results: The double PRP infusion group exhibited measurable improvements in endometrial and early pregnancy outcomes. 1) Endometrial thickness increased (8.42 ± 0.53 mm vs 7.96 ± 0.45 mm, P<0.01); 2) Hemodynamic parameters improved for resistance index (RI) (1.72 ± 0.08 vs 1.79 ± 0.08, P<0.01) and pulsatility index (PI) (3.83 ± 0.64 vs 4.38 ± 0.68, P<0.01); 3) Clinical outcomes: lower cycle cancellation rate (10.0% vs 26.0%, P=0.037) and higher clinical pregnancy rate (48.9% vs 27.0%, P=0.043).However, early miscarriage rates were similar between groups (p > 0.99). Conclusion: Compared to a single intrauterine infusion, double intrauterine PRP infusion may enhance the receptivity of a thin endom...