The epidemiology and hypervirulence of Klebsiella pneumoniae ST23 unveil epidemic risks in China and worldwide

作者：Haijian Zhou, Chongye Guo, Zhigang Cui, Jinrui Hu, Xiaoli Du, Yan V. Sun, Linhuan Wu, Biao Kan · 发表于：The Lancet Regional Health - Western Pacific · 年份：2025 · DOI：10.1016/j.lanwpc.2025.101661 · 被引用次数：5 · 研究领域：Antibiotic Resistance in Bacteria、Bacteriophages and microbial interactions、Pneumonia and Respiratory Infections

The global dissemination of Klebsiella pneumoniae (KP),1 particularly the emergence of strains with multiple-drug resistance and hyper-virulence underscores the critical epidemiological threat worldwide. As a result, we conducted genomic surveillance to assess the hyper-virulence and transferable antibiotic resistance risks associated with various KP sequence types (STs). Our findings reveal that ST23, characterized by a high prevalence of hyper-virulence and rapidly increasing dissemination potential, may poses a substantial public health threat considering its potential ability for horizontal transfer of carbapenem-resistant genes.