A 74-Year-Old Woman with Leg Weakness

作者：Florence Morriello, Justin Chiu · 发表于：NEJM Evidence · 年份：2025 · DOI：10.1056/evidmr2400472 · 研究领域：Peripheral Neuropathies and Disorders、Autoimmune Neurological Disorders and Treatments、Drug-Induced Ocular Toxicity

AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts to collaboratively examine an interesting patient's presentation. The Morning Report section seeks to carry on this tradition by presenting a patient's chief concern and story, inviting the reader to develop a differential diagnosis and discover the diagnosis alongside the authors of the case. This report examines the story of a 74-year-old woman who presents to the emergency department with a 3-month history of bilateral leg weakness and paresthesia. Using questions, physical examination, and testing, an illness script for the presentation emerges. As the clinical course progresses, the differential is refined until a final diagnosis is made.