Contemporary Changes in Global Trends in Early-Onset Cancer: Incidence and Mortality (2000–2021)

作者：Pojsakorn Danpanichkul, Yanfang Pang, Supapitch Sirimangklanurak, Thanida Auttapracha, Thanawin Pramotedham, Chun‐Wei Pan, Benjamin Koh, Zhen Yu Wong, Sakditad Saowapa, Shyna Zhuoying Gunalan, Kwanjit Duangsonk, Chanakarn Kanitthamniyom, Donghee Kim, Karn Wijarnpreecha, Amit G. Singal, Daniel Q. Huang, Ju Dong Yang · 发表于：Cancers · 年份：2025 · DOI：10.3390/cancers17172766 · 被引用次数：6 · 研究领域：Global Cancer Incidence and Screening、Bladder and Urothelial Cancer Treatments、Cancer Risks and Factors

Background/Objectives: The burden of early-onset cancer (cancer incidence <50 years) has increased globally. Early-onset cancer carries significant societal and economic consequences. We aim to provide updated estimates for incidence and mortality of early-onset cancer. Methods: We analyzed the Global Burden of Disease Study 2021 to describe the incidence, death, age-standardized incidence rate (ASIR), age-standardized death rate (ASDR) from early-onset cancer (i.e., cancer in people aged 15–49), and its changes from 2000 to 2021 (reflected as annual percent change [APC]), using Joinpoint regression analysis. Results: In 2021, there were 3.16 million new cases and 989,650 deaths from early-onset cancer. From 2000 to 2021, the ASIR of early-onset cancer increased (APC: 0.40%, 95% CI 0.32 to 0.47%), with the highest increase observed in the Eastern Mediterranean region (APC: 1.63%, 95% CI 1.53 to 1.72%), whereas the ASDR decreased across most regions. The ASIR for early-onset cancer had a higher increase in females (APC: 0.62%, 95% CI 0.51 to 0.73%) than males (APC: 0.14%, 95% CI 0.04 to 0.23%). Breast cancer (n = 567,900) constituted the highest burden of incident cases, followed by non-melanoma skin (n = 507,810) and cervical cancers (n = 307,430). The highest increase in the ASIR was observed in non-melanoma skin cancer (APC:2.18%, 95% CI 1.85–2.51%), thyroid (APC: 1.70%, 95% CI 1.60 to 1.79%), and testicular (APC:1.37%, 95% CI 0.96 to 1.78%) cancers. The greatest increases ...