Fe(OTf) 3 -Catalyzed Diastereoselective Synthesis of α-Aminophosphonates via Phosphorylation of N,O -Acetals

作者：Jian‐Ting Sun, Xin Li, Yu Zhang, Xiaolin Liu, Bang‐Guo Wei · 发表于：The Journal of Organic Chemistry · 年份：2025 · DOI：10.1021/acs.joc.5c01554 · 被引用次数：4 · 研究领域：Organophosphorus compounds synthesis、Asymmetric Hydrogenation and Catalysis、Ferrocene Chemistry and Applications

An efficient approach to α - aminophosphonates has been developed through an Fe(OTf) 3 -catalyzed N- α phosphonylation of N,O -acetals with triethyl phosphite. As a result, a series of 2,6- cis and 2,5- trans α - aminophosphonates were obtained in moderate to excellent yields and with excellent diastereoselectivities ( dr up to 19:1).