Pillarureaarenes: Urea-Embedded Pillararenes for Amino Acid Derivative Recognition

作者：Kai Diao, Wang Xie, Mingyue Wen, Wenhao Lin, Qing Liu, Shengke Li, Robert B. P. Elmes, Tangxin Xiao, Leyong Wang · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c03042 · 被引用次数：8 · 研究领域：Supramolecular Chemistry and Complexes、Molecular Sensors and Ion Detection、Supramolecular Self-Assembly in Materials

A three-dimensional pillarureaarene ( P3U6A ) was synthesized via fragment-coupling cyclization of dialkoxybenzene and urea units. Single-crystal analysis revealed a shield-shaped structure stabilized by intramolecular hydrogen bonds. The macrocycle demonstrated strong binding with phenylalanine ethyl ester salts. Further derivatization gave P3EU6A, showing chiral recognition of a series of amino acid derivatives via induced circular dichroism (CD). This work introduces a versatile platform for constructing urea-embedded pillararenes with potential applications in host–guest chemistry and chirality sensing.