Traumatic Brain Injury and Risk of Malignant Brain Tumors in Civilian Populations

作者：Sandro Marini, Amr Alwakeal, Hunter Mills, Joshua D. Bernstock, Ahmad Mashlah, Muhammad T. Hassan, Jakob V. E. Gerstl, Farid Radmanesh, Gundolf Schenk, Sharat Israni, Rachel Grashow, E. Antonio Chiocca, Cathra Halabi, Anthony M. DiGiorgio, Stephen T. Magill, Geoffrey T. Manley, Saef Izzy, Ross Zafonte · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.28850 · 被引用次数：6 · 研究领域：Traumatic Brain Injury Research、Traumatic Brain Injury and Neurovascular Disturbances、Trauma and Emergency Care Studies

Importance: A 2024 US study reported that veterans of the Iraq and Afghanistan wars affected by traumatic brain injury (TBI) had an increased risk of developing brain tumors. However, studies among civilians have shown conflicting results and have not replicated the association between TBI and brain tumor risk. Objective: To examine whether history of TBI in US adult civilians is associated with a risk of subsequent development of malignant brain tumors. Design, Setting, and Participants: This retrospective cohort study used data from a tertiary academic medical center (Mass General Brigham [MGB]) patient data registry encompassing January 1, 2000, to January 1, 2024. Adult patients (aged >18 years) with mild TBI or moderate to severe TBI (exposure group) were compared with an age- and sex-matched group without a history of TBI (control group). The MGB data were compared across the same time span with data from 2 other tertiary academic medical centers (University of California [UC] Health Data Warehouse and Northwestern Medicine). Exposure: TBI, which was categorized by severity as mild or moderate to severe. Main Outcomes and Measures: The primary outcome was development of malignant brain tumor based on International Classification of Diseases, Ninth Revision (ICD-9) and Tenth Revision (ICD-10) diagnostic codes in the patient data registry of each cohort. Cox proportional hazards regression analysis was used to determine whether TBI was associated with brain tumor developm...