Endothelial mitochondria in the blood-brain barrier

作者：Yun Shao, Lingling Mai, Ruogu Qiao, Yi Liang, Yuying Jiao, Justus Homburg, Zhenfu Jiang, Laiyu Song · 发表于：Fluids and Barriers of the CNS · 年份：2025 · DOI：10.1186/s12987-025-00699-w · 被引用次数：20 · 研究领域：Mitochondrial Function and Pathology、Metabolism and Genetic Disorders、Alzheimer's disease research and treatments

The blood-brain barrier (BBB) is a highly selective interface between the peripheral circulation and the central nervous system (CNS), crucial for maintaining brain homeostasis. Disruptions to the BBB, such as increased permeability or structural damage, can lead to neurological damage. Mitochondria, the primary energy producers within endothelial cells, play a key role in the function of the BBB by maintaining its integrity and low permeability. This review first outlines the structural components of the BBB, then examines the role of mitochondria in endothelial cells under physiological conditions. We further focus on alterations in mitochondrial function during pathological states, discussing their impact on BBB stability. Briefly, this review explores the involvement of mitochondria in BBB endothelial cells in both physiological processes and the pathological progression of neurological diseases, while proposing potential therapeutic directions for treating CNS disorders. Shao et al. integrated existing knowledge on the impact of mitochondrial function on the stability of the BBB, demonstrating that mitochondrial dysfunction can compromise BBB integrity and stability, for instance, by inducing mitochondrial dynamics imbalance, the BBB can be directly damaged, thereby promoting the onset and progression of neurological diseases. They emphasized that exploring the specific mechanisms of mitochondrial transfer is crucial for identifying new therapeutic strategies for neurolo...