MnOx nanoflower-based ultrasound-responsive drug delivery for sonodynamic therapy of wound infections

作者：Jia Xu, Yi Liu, Guangzheng Zhang, Jinmei Wu, Xujie Cui, Wenqing Wei, Ziyan Yuan, Lin‐Lin Bu, Heyou Han, Weihui Li, Zhiyong Song · 发表于：Ultrasonics Sonochemistry · 年份：2025 · DOI：10.1016/j.ultsonch.2025.107530 · 被引用次数：6 · 研究领域：Nanoplatforms for cancer theranostics、Bone Tissue Engineering Materials、Electrospun Nanofibers in Biomedical Applications

The rapid spread of drug-resistant bacterial infections has become a major global health challenge, particularly in the treatment of deep organ abscesses, which often lead to severe and life-threatening infections. Traditional light-responsive and microenvironment-responsive nanoparticle drug delivery systems (DDSs) have limitations in treating deep abscesses. In contrast, ultrasound (US)-driven sonodynamic therapy (SDT), with its non-invasive, targeted radiation and excellent tissue penetration capabilities, offers great potential for eradicating deep bacterial infections. This study proposes an ultrasound-driven manganese-based nanoparticle drug delivery system (AMP) for the effective treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. The core of the system is manganese oxide (MnOx) nanoflowers, which serve as the nanoparticle carrier, loaded with the antimicrobial non-antibiotic drug auranofin, and surface-modified with polyethylene glycol to enhance its biocompatibility and drug delivery performance. AMP demonstrates significant antibacterial activity in vitro and effectively promotes wound healing under US-driven stimulation. Furthermore, the potential antibacterial and wound-healing mechanisms of AMP are revealed for the first time. This study cleverly combines non-antibiotic drugs with inorganic nanomaterials to successfully achieve efficient SDT, providing a new and effective strategy for treating deep bacterial infections.