The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma

作者：Rongrong Liu, Xinyan Li, Jiayi Xu, Liangwen Yan, Kui Hu, Mengjiao Shi, Yinggang Zhang, Yaping Zhao, Yudan Fan, Gang Wang, Ying Guo, Yetong Feng, Pengfei Liu · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.115661 · 被引用次数：18 · 研究领域：Ferroptosis and cancer prognosis、RNA modifications and cancer、Epigenetics and DNA Methylation

: Overall, our results highlight the significant role of VPA in differentially regulating ferroptosis and disulfidptosis in HCC cells, thereby offering a precise avenue for addressing drug-resistant HCC in clinical practice.