Neutrophil extracellular traps induce endothelial damage and exacerbate vasospasm in traumatic brain injury

作者：Jinchao Wang, Lei Li, Jianye Xu, Dilmurat Gheyret, Kaiji Li, Xu Zhang, Haoran Jia, Ye Tian, Xiao Liu, Shenghui Li, Guili Yang, Yalong Gao, Ruilong Peng, Huajie Liu, Bin Liu, Jianfeng Zhuang, Cong Wang, Xin Chen, Yafan Liu, B. Chen, Chuan Huang, Yuhan Li, Xin Chen, Jianning Zhang, Jianning Zhang · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.115746 · 被引用次数：11 · 研究领域：Traumatic Brain Injury and Neurovascular Disturbances、Intracranial Aneurysms: Treatment and Complications、Neutrophil, Myeloperoxidase and Oxidative Mechanisms

These findings identify TREM1 as a promising therapeutic target and illuminate a NET-driven crosstalk between vascular dysfunction and inflammatory cascades in the context of TBI, offering novel translational insights for mitigating secondary brain injury.