Multifunctional Polyrotaxane Hydrogel with Dynamic Molecular Anchors and Microenvironment-Activatable Cationization Properties for Healing Drug-Resistant Bacterial-Infected Chronic Skin Wounds

作者：Jian Wu, Zhen Wang, Hui Xing, Ying Zhang, Ying Zhang, Tao Liu, Yi Zhang, Yi Zhang, Dong Ma · 发表于：ACS Applied Materials & Interfaces · 年份：2025 · DOI：10.1021/acsami.5c13640 · 被引用次数：6 · 研究领域：Wound Healing and Treatments、Antimicrobial agents and applications、Burn Injury Management and Outcomes

The wound healing process in diabetic patients is often complex and prolonged, frequently complicated by persistent bacterial infections that can develop into multidrug-resistant infections, posing significant challenges for treatment. However, traditional hydrogel dressings often exhibit limited efficacy against complex wounds, primarily because therapeutic molecules are confined within the cross-linked matrix and exert nonselective antibacterial effects. This study developed a novel polyrotaxane-based hydrogel (FDS) against diabetic wounds complicated by drug-resistant bacterial infections. By assembling SNO-modified β-cyclodextrin onto the F-127DA copolymer backbone and copolymerized with dimethylamino propyl methacrylamide (DMAPMA), FDS hydrogel was endowed with conformational freedom of NO (Nitric Oxide) donor through rotatable and slidable motions and acid-responsive antibacterial properties simultaneously. This FDS hydrogel exhibited excellent antibacterial (both Staphylococcus aureus and methicillin-resistant S. aureus ) and biofilm-dispersing effects, NO-enhanced angiogenesis, significantly reduced inflammatory response, and accelerated healing of chronic diabetic wounds in vitro and in vivo . By virtue of movable molecular anchoring facilitated NO delivery and microenvironment-activatable antibacterial activity, this research offers new hope for addressing the challenges of wound healing in diabetic patients accompanied by bacterial infections.