Preconception lifestyle interventions for women—a systematic review and meta-analysis of intervention characteristics and behaviour change techniques

作者：Sophia Torkel, Evangeline Mantzioris, Anthony Villani, Nicole J. Kellow, Dhruv Bhatnagar, Elaine K. Osei‐Safo, Margaret Μ. McGowan, Nur K. Abdul Jafar, Nadia Bogatzke, Simon Alesi, Tuba Astarcioglu, Ben W. Mol, Robert J. Norman, Stephanie Cowan, Rui Wang, Lisa Moran · 发表于：Human Reproduction Update · 年份：2025 · DOI：10.1093/humupd/dmaf021 · 被引用次数：4 · 研究领域：Reproductive Health and Contraception、Ovarian function and disorders、Reproductive Health and Technologies

BACKGROUND: The time before conception is an important opportunity to improve maternal lifestyle, and hence improve fertility and health. However, the components of effective preconception lifestyle interventions are unclear. OBJECTIVE AND RATIONALE: This review aimed to assess the association of intervention characteristics and behaviour change techniques with the effect of lifestyle interventions on fertility, obstetric, foetal, anthropometric, and metabolic outcomes in women planning a pregnancy. Understanding the optimal components of preconception lifestyle interventions is essential to improve success of future interventions. SEARCH METHODS: We searched Ovid MEDLINE, PsycINFO, Embase, Emcare, Scopus, Cochrane Central Register of Controlled Trials, and CINAHL (6 December 2024). We included randomized controlled trials on women planning a pregnancy which assessed the effect of lifestyle intervention compared to standard minimal care or no intervention on fertility, obstetric, foetal, anthropometric, and metabolic outcomes. We performed random-effects meta-analysis with subgroup analysis based on participant characteristics, intervention characteristics (using the Template for Intervention Description and Replication (TIDieR) framework), and behaviour change techniques (using the Behaviour Change Taxonomy v1). We assessed trustworthiness (using the Trustworthiness in Randomised Controlled Trials (TRACT) checklist), risk of bias (using the Cochrane Risk of Bias 2.0 tool), a...