Relationship between metabolic syndrome and overactive bladder: insights from the NHANES and Mendelian randomization study

作者：Zhihao Liu, Xiaotong Sun, Chunlei Liu, Che Wang, Rujie Zheng, Xiaoyu Du, Wenjuan Song, Chengzhi Lu · 发表于：Diabetology & Metabolic Syndrome · 年份：2025 · DOI：10.1186/s13098-025-01883-6 · 被引用次数：2 · 研究领域：Urinary Bladder and Prostate Research、Bladder and Urothelial Cancer Treatments、Urological Disorders and Treatments

PURPOSE: Clinical observations suggest a correlation between metabolic syndrome (Mets) and overactive bladder (OAB). However, the absence of evidence for a direct causal relationship between them limits the development of effective treatment strategies. This study aimed to explore the association between Mets and OAB in the U.S. population and elucidate their causal relationships. METHODS: A cross-sectional study was conducted using data from the 2005-2018 National Health and Nutrition Examination Survey (NHANES). OAB symptoms were assessed using the OAB symptom score (OABSS), and Mets was diagnosed based on the NCEP-ATP III criteria. Multivariate logistic regression was used to evaluate the relationship between Mets and OAB. Subgroup analyses and interaction tests were performed to assess the consistency of this association. Mendelian randomization (MR) analysis was conducted to investigate the causal effects of Mets components or risk factors on OAB symptoms, including bladder calcification /contracture/ overactivity (BCCO) and urinary frequency/incontinence (UFI). RESULTS: The cross-sectional study involved 7,596 participants. After adjusting for covariates, individuals with Mets had a significantly higher risk of OAB (OR: 2.27, 95% CI: 1.89-2.72, p = 0.035). Gender subgroup analysis revealed that females had 51% higher odds of developing OAB compared to the reference group (OR: 1.51, 95% CI: 1.13-2.02, p = 0.008), while this association was not observed in males (OR: 0.95...