Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy

作者：Judy Chen, Alexander Ngo, Raúl Rodríguez‐Cruces, Jessica Royer, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S. Keller, Fernando Cendes, Clarissa Lin Yasuda, Marina K. M. Alvim, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K. Focke, Barbara A. K. Kreilkamp, Martin Domín, Felix von Podewils, Sönke Langner, Christian Rummel, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Benjamin Bender, Terence J. O’Brien, Benjamin Sinclair, Lucy Vivash, Patrick Kwan, Patricia Desmond, Elaine Lui, Gian Marco Duma, Paolo Bonanni, Alice Ballerini, Anna Elisabetta Vaudano, Stefano Meletti, Manuela Tondelli, Saud Alhusaini, Colin P. Doherty, Gianpiero L. Cavalleri, Norman Delanty, Reetta Kälviäinen, Graeme D. Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H. Thomas, Hamid Soltanian‐Zadeh, Esmaeil Davoodi‐Bojd, Junsong Zhang, Matteo Lenge, Renzo Guerrini, Emanuele Bartolini, Khalid Hamandi, Sonya Foley, Theodor Rüber, Tobias Bauer, Bernd Weber, Benoît Caldairou, Chantal Depondt, Julie Absil, Sarah J. A. Carr, Eugenio Abela, Mark P. Richardson, Orrin Devinsky, Heath Pardoe, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Erik Kaestner, Sean N. Hatton, Donatello Arienzo, Sjoerd B. Vos, Mina Ryten, Peter N. Taylor, John S. Duncan, Christopher D. Whelan, Marian Galovic, Gavin P. Winston, Sophia I. Thomopoulos, Paul M. Thompson, Sanjay M. Sisodiya, Angelo Labate, Carrie R. McDonald, Lorenzo Caciagli, Neda Bernasconi, Andrea Bernasconi, Sara Larivière, Dewi Schrader, Boris C. Bernhardt · 发表于：Neurology · 年份：2025 · DOI：10.1212/wnl.0000000000213688 · 被引用次数：7 · 研究领域：Epilepsy research and treatment、Functional Brain Connectivity Studies、Psychosomatic Disorders and Their Treatments

BACKGROUND AND OBJECTIVES: Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of gray and white matter structures. Evidence supports a progressive condition, although the temporal evolution of TLE is poorly defined. In this ENIGMA-Epilepsy study, we aim to investigate structural alterations in gray and white matter across the adult lifespan in patients with TLE by charting both gray and white matter changes and explore the covariance of age-related alterations in both compartments. METHODS: scores of all patients. Covariance analyses examined the coupled correlations of gray and white matter lifespan curves for each region. RESULTS: < 0.05). Changes spanned the adult time window and effects exceeded typical aging-related processes in patients at the level of cortical thickness, subcortical volume, and diffusion measures, particularly in patients older than 55 years. Covariance analyses revealed strong associations across multiple white matter tracts, subcortical structures, and cortical regions within and beyond the temporolimbic system. DISCUSSION: This study highlights that patients with TLE exhibit more pronounced and widespread gray and white matter atrophy across the lifespan. The cross-sectional nature of our study limits definitive conclusions on whether the atrophy shown is progressive but emphasizes the importance of prompt diagnosis and intervention in patients. Collectively, our results motivate future longit...