Impact of social deprivation upon the preoperative pathway and early surgical outcomes after pancreatoduodenectomy for PDAC and non-PDAC periampullary cancer in England: the Surg-Panc-UK study

作者：Thomas Thorne, Siobhan McKay, Samir Pathak, Richard Wilkin, Jenifer Barrie, John Moir, Keith Roberts, Keith J. Roberts, Siobhan C. McKay, Thomas Thorne, Samir Pathak, Richard JW. Wilkin, Jenifer Barrie, John Moir, Keith Roberts, Keith Roberts, R.C. Dawson, Kazim Abbas, M Taggarsi, Bristol Royal Infirmary, Samir Pathak, Jozel Ramirez, S. Biggs, Christopher Vaz, Fiona Teeling, Warwick, Gabriele Marangoni, Jawad Ahmad, Qazi Muhammad, Greg Williams, Edinburgh Royal Infirmary, Ewen M. Harrison, Francis Robertson, Fiona Hand, Glasgow Royal Infirmary, Euan J. Dickson, Nigel Jamieson, David Holroyd, Catherine W. McCollum, Sean McCafferty, Madhava Pai, Tamara Gall, Hull Royal Infirmary, Pavlos Lykoudis, Jenifer Barrie, Hannah Wynn, Parthi Srinivasan, Crispin C. Schneider, Alaa Jawad Hassan, J. P. Leahy, Alistair Young, Usman Kokhar, Nikhil Suresh, Giuseppe Garcea, John Isherwood, Aayush Sinha, Tareq Alsaoudi, Eyad Issa, Bishow Karki, Paula Ghaneh, Sivasanker Masillamny, Nicola de Liguori Carino, Sutharsan Yoganathan, Gourab Sen, J. Mori, F Abbadessa, Dhya Al-Leswas, Corey D. Chan, Somiah Aroori, Anastasia Benjafield, Keith Roberts, Keith Roberts, Jessica Chauhan, Siobhan C. McKay, Alex McDonald, David Nasralla, Joerg‐Matthias Pollok, Pascale Tinguely, J. Celestino da Costa, Hemant M. Kocher, Deepak Hariharan, Johnathon Cann, Mohamed Zardab, Konstantinos Stasinos, Ricky Bhogal, Long R. Jiao, Rachna Goburdhun, Ali Arshad, Claire Stevens, Nehal Shah, Jenifer Barrie, Dillon Vyas, Tejinder Athwal, Nader Ghassemi, Alyssa Ralph, Joseph Meilak, Yanish Poolovadoo, Adam Frampton, Sudip Samyal, O Oyende, Benjamin Varghese, Alfred Adiamah, Melroy Rasquinha · 发表于：HPB · 年份：2025 · DOI：10.1016/j.hpb.2025.07.007 · 研究领域：Pancreatic and Hepatic Oncology Research、Cholangiocarcinoma and Gallbladder Cancer Studies、Global Cancer Incidence and Screening

BACKGROUND: Socioeconomic deprivation is linked to poorer outcomes in many cancers, however the impact of social deprivation on survival in resectable pancreatic and other peri-ampullary cancers appears mixed. Moreover, no studies consider the impact of social deprivation on diagnostic pathway length. METHODS: A retrospective observational cohort study of adults with suspected periampullary cancer undergoing pancreaticoduodenectomy in England. Following surgery, patients were stratified by cancer type (PDAC, duodenal cancer, cholangiocarcinoma and ampullary cancer) and the impact of social deprivation (IMD deprivation quintiles) upon short-term survival and diagnostic pathway length analysed. RESULTS: 648 patients from England with social deprivation data were identified, including PDAC (n = 386) and non-PDAC periampullary malignancies (n = 262). For PDAC and non-PDAC patients, there was no association between resection rate and IMD quintile (p = 0.172 and p = 0.084). For PDAC patients, no difference in neoadjuvant chemotherapy rates (p = 0.462) or 1-year survival (p = 0.052) existed across IMD quintiles. DISCUSSION: Across England socioeconomic deprivation does not appear to relate to survival outcomes after PD for periampullary cancer, regardless of histological subtype. This suggests that pancreatic resectional centres are managing health inequality well.