Acute effects of low-dose bisoprolol on lung function and blood pressure in COPD patients

作者：Thomas Bradbury, Allison Martin, Robert J. Hancox, Catherina L. Chang, Richard Beasley, Jérémy Wrobel, Vanessa M. McDonald, Claudia C. Dobler, Ian A. Yang, Claude S. Farah, Belinda Cochrane, Graham S. Hillis, Caroline Polak Scowcroft, Ashutosh N. Aggarwal, Channa D Ranasinha, Shane Galgey, Christine Jenkins · 发表于：ERJ Open Research · 年份：2025 · DOI：10.1183/23120541.00591-2025 · 被引用次数：1 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Pulmonary Hypertension Research and Treatments、Respiratory Support and Mechanisms

Background and objective Recent observational data suggest that cardioselective β-blockers like bisoprolol are safe and beneficial for patients with COPD. However, the acute effects of bisoprolol on lung and cardiovascular function in these patients is unclear, a gap that this study aimed to address. Methods This was a subanalysis of pre-randomisation screening visit data from the ongoing Preventing Adverse Cardiac Events (PACE) in COPD randomised controlled trial. If all other eligibility criteria were met, participants were orally administered an unblinded 1.25 mg tablet of bisoprolol. Post-bronchodilator spirometry, heart rate and blood pressure were monitored at 0, 30 (cardiovascular parameters only), 60 and 120 min. For this subanalysis, respiratory intolerance was defined as a decrease in forced expiratory volume in 1 s (FEV 1 ) (L) ≥200 mL and ≥12% from the 0-min FEV 1 (L) value; and cardiovascular intolerance was defined as systolic blood pressure (SBP) falling below 100 mmHg at 1 or 2 h. Results Of 359 consented participants, 292 conducted the test-dose procedure. 13 (4.5%) were respiratory intolerant and six (2.1%) were cardiovascular intolerant at 1 or 2 h. No participant was intolerant for both. There was no significant difference in FEV 1 (L) or SBP at baseline At 120 min the intolerant group's mean FEV 1 had significantly decreased to 1.05 L (95% CI 0.86–1.25 L; p<0.0001); the tolerant group experienced no change (1.10, 1.05–1.14 L; p=0.33). Conclusion The ad...