Blood Eosinophil Stability Predicts Clinical Outcomes in Hospitalized Patients with Acute Exacerbations of COPD

作者：Lujia Guan, Jiachen Li, Lirong Liang, Zhaohui Tong · 发表于：International Journal of COPD · 年份：2025 · DOI：10.2147/copd.s536911 · 被引用次数：2 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Asthma and respiratory diseases、Delphi Technique in Research

Background and Objective: Blood eosinophil (EOS) levels are considered a potential biomarker for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) management, but the impact of EOS stability during hospitalization on outcomes is unclear. This study examined the relationship between EOS stability and clinical outcomes in these patients. Methods: A retrospective analysis was conducted on 2105 AECOPD patients hospitalized at Beijing Chao-Yang Hospital from 2013 to 2022. Patients were classified into four groups according to EOS counts (2%) at admission and discharge: persistent high, decreased, increased, and persistent low. Clinical characteristics and outcomes were compared between EOS stability groups. Multivariable logistic regression was used to evaluate the association between EOS stability and adverse hospital outcomes. Cox regression analysis was performed to assess the risk of AECOPD-related readmission within three years. Receiver operating characteristic (ROC) curves and nomograms were used to evaluate the predictive performance of the models. Results: There were 586 (27.8%), 154 (7.3%), 593 (28.2%), and 772 (36.7%) patients in the persistent high, decreased, increased, and persistent low groups, respectively. Multivariable logistic regression analysis showed that the persistent high EOS group had a significantly lower risk of adverse hospital outcomes compared to the persistent low EOS group (aOR: 0.77, 95% CI: 0.59– 0.99, P = 0.040). The nomogram ...