Diversity-Enhanced Collaborative Mamba for Semi-Supervised Medical Image Segmentation

作者：Shumeng Li, Jian Zhang, Lei Qi, Luping Zhou, Yinghuan Shi, Yang Gao · 发表于：IEEE Transactions on Medical Imaging · 年份：2025 · DOI：10.1109/tmi.2025.3601450 · 被引用次数：4 · 研究领域：Brain Tumor Detection and Classification、Medical Image Segmentation Techniques、Advanced Neural Network Applications

Acquiring high-quality annotated data for medical image segmentation is tedious and costly. Semi-supervised segmentation techniques alleviate this burden by leveraging unlabeled data to generate pseudo labels. Recently, advanced state space models, represented by Mamba, have shown efficient handling of long-range dependencies. This drives us to explore their potential in semi-supervised medical image segmentation. In this paper, we propose a novel Diversity-enhanced Collaborative Mamba framework (namely DCMamba) for semi-supervised medical image segmentation, which explores and utilizes the diversity from data, network, and feature perspectives. Firstly, from the data perspective, we develop patch-level weak-strong mixing augmentation with Mamba's scanning modeling characteristics. Moreover, from the network perspective, we introduce a diverse-scan collaboration module, which could benefit from the prediction discrepancies arising from different scanning directions. Furthermore, from the feature perspective, we adopt an uncertainty-weighted contrastive learning mechanism to enhance the diversity of feature representation. Experiments demonstrate that our DCMamba significantly outperforms other semi-supervised medical image segmentation methods, e.g., yielding the latest SSM-based method by 6.69% on the Synapse dataset with 20% labeled data. The code is available at https://github.com/ShumengLI/DCMamba.