Palladium-Catalyzed Cycloisomerization of Bicyclobutyl (BCB) Amides to Access Polycyclic Quinolinones

作者：Jianwei Wang, Yan Cao, Linqi Wang, Jun Ying · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c03075 · 被引用次数：8 · 研究领域：Cyclopropane Reaction Mechanisms、Catalytic Alkyne Reactions、Catalytic C–H Functionalization Methods

A novel palladium-catalyzed cycloisomerization of bicyclobutyl amides has been developed for the expedited construction of polycyclic quinolinone skeletons. The reaction proceeded well to furnish a variety of tetracyclic quinolinone derivatives in good yields. Additionally, scale-up reactions and derivatization of tetracyclic quinolinones were demonstrated as well.