Improving chemotherapy-induced peripheral neuropathy in cancer patients using a combined qigong and self-administered acupressure intervention: a randomized controlled trial

作者：Denise Shuk Ting Cheung, Wing‐Fai Yeung, Pui Hing Chau, Sammy Chan, Wing‐Lok Chan, Chao Hsing Yeh, Lixing Lao, Ziyu Zhang, Chia‐Chin Lin · 发表于：ESMO Open · 年份：2025 · DOI：10.1016/j.esmoop.2025.105565 · 被引用次数：6 · 研究领域：Biofield Effects and Biophysics、Cancer Treatment and Pharmacology、Cancer-related cognitive impairment studies

BACKGROUND: Acupressure and qigong are Chinese medicine-based modalities that can work in synergy to improve chemotherapy-induced peripheral neuropathy (CIPN). This study examines the effect of a combined qigong and acupressure intervention on CIPN among cancer patients. PATIENTS AND METHODS: This randomized controlled trial included cancer patients experiencing CIPN. Participants were randomly allocated to intervention and waitlist control groups (1 : 1). The intervention group received a 16-week combined qigong and self-administered acupressure intervention. The primary outcome was self-reported CIPN severity (Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity). Other outcomes included objectively measured CIPN severity (DPNCheck), handgrip strength (dynamometer), physical performance (Short Physical Performance Battery), fall incidence, and health-related quality of life (HRQoL, Functional Assessment of Cancer Therapy-General). Data were collected at baseline, 16 weeks, and 28 weeks. Intention-to-treat analysis was carried out. RESULTS: The study randomly assigned 110 patients [mean (standard deviation) age 61.86 years (9.31 years); 49 (89.1%) female], among whom 103 completed the study. After intervention, the reduction in self-reported CIPN severity in the intervention group was significantly larger than in the control group (mean difference = -3.86, 95% confidence interval CI -6.14 to -1.58), P = 0.001). The intervention showed significant ...