Multifunctional Nanoplatform Combining Photothermal Therapy and Chemoimmunotherapy for the Treatment of Escherichia coli -Colonized Colorectal Cancer

作者：Maolin Li, Yin Liu, Dandan Han, Songgu Wu, Junbo Gong · 发表于：Biomacromolecules · 年份：2025 · DOI：10.1021/acs.biomac.5c01170 · 被引用次数：3 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Photodynamic Therapy Research Studies

The presence of bacteria in colorectal cancer not only induces drug inactivation but also inhibits the antitumor immune responses. Here, a multifunctional nanoplatform (IR/CP@BNP@HA) is designed to enhance antitumor photothermal therapy and chemoimmunotherapy for the treatment of bacterium-infected tumors. IR/CP@BNP@HA consists of the hyaluronic acid (HA) shell and reactive oxygen species (ROS)-responsive chitosan biguanide-functionalized biopolymer core (IR/CP@BNP), which encapsulates chemotherapy drug camptothecin (CPT) and photothermal agent IR1048. IR/CP@BNP@HA actively targeted the tumor and was subsequently degraded by abundant hyaluronidase (HAase) present in the extracellular matrix. The resultant IR/CP@BNP exhibited a size decrease and charge reversal, which facilitated a deep tumor penetration. After internalization, the exposed guanidine group of IR/CP@BNP effectively eliminated intracellular bacteria and accomplished lysosome escape. Additionally, intracellular ROS induced the precise release of drugs. More importantly, IR/CP@BNP@HA also promoted dendritic cell maturation, which in turn facilitated T-cell infiltration and maximized the antitumor immune response.