Prediction of CD8+ T cell infiltration in the tumor microenvironment of HGSOC patients

作者：Jia Mai, Ling Yang, Yuxin Chen, Xianlu Zeng, HongJian Xie, Xiaojuan Liu · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-14720-7 · 被引用次数：5 · 研究领域：Cancer Immunotherapy and Biomarkers、Renal cell carcinoma treatment、Lymphoma Diagnosis and Treatment

The tumor microenvironment (TME), particularly CD8 + T cell infiltration, critically influences high-grade serous ovarian cancer (HGSOC) progression and treatment response. The development and management of cancer depend heavily on CD8 + T cells. Identifying non-invasive predictors of TME immune status is crucial. We investigated whether clinicopathologic characteristics and peripheral blood parameters could predict CD8 + T infiltration in TME of HGSOC. Two independent cohort were analyzed: (1) A multicenter tissue microarray (TMA) cohort of 105 epithelial ovarian cancer cases revealed that high CD8 + T cell density in tumor parenchyma, stroma, or whole tissue was significantly associated with good prognosis. (2) A retrospective cohort of 95 HGSOC patients from West China Second University Hospital (2016–2020) demonstrated that peripheral blood lymphocytes, globulin (GLB), lactate dehydrogenase (LDH), and low-density lipoprotein (LDL) correlated with CD8 + T cell infiltration in TME. These findings support non-invasive blood markers as predictors of tumor immune status and highlight chemotherapy’s role in enhancing CD8 + T cell recruitment.