Profile of central line-associated bloodstream infections in adult, paediatric, and neonatal intensive care units of hospitals participating in a health-care-associated infection surveillance network in India: a 7-year multicentric study

作者：Rasna Parveen, Arpan Kumar Thakur, Sharad Srivastav, Mamta Puraswani, Ashish Kumar Srivastava, Arunaloke Chakrabarti, Camilla Rodrigues, Pallab Ray, Manisha Biswal, Neelam Taneja, Chand Wattal, Vimala Venkatesh, Nandini Sethuraman, Sanjay Bhattacharya, Vijaya Lakshmi Nag, Vibhor Tak, Bijayini Behera, Veeraragavan Balaji, Raja Ray, Sanjeev Singh, Chiranjay Mukhopadhyay, Joy Sarojini Michael, Bashir Ahmad Fomda, Tadepalli Karuna, Vijayshri Deotale, Padma Das, Amber Prasad, Tapan Majumder, Puneet Kumar Gupta, Kanne Padmaja, Purva Mathur, Vijeta Bajpai, Jyoti Iravane, Reema Nath, Renu Gur, Nari M Lyngdoh, Clarissa Jane Lyngdoh, Sheela Devi, Shalini Malhotra, Rajni Gaind, Ranjana Devi Khuraijam, Rajni Sharma, Summaiya Mullan, John Antony Jude Prakash, Shaoli Basu, Hema Paul, Priscilla Rupali, Sheetal Verma, MA Thirunarayan, Hirak Jyoti Raj, R. Saxena, Sangita Rajdev, Neeraj Goel, Sudipta Mukherjee, Yamunadevi Ramanathan, Juliah Chelliah, Satyam Mukherjee, Archana Angrup, Aparna Sonowal, Veena Kumari, Prachi Verma, Jayashree Muralidharan, Ritesh Agarwal, Lakshmi Narayana Yaddanapudi, Ajay Duseja, K. K. Jain, Usha R. Dutta, Parthasarathi Bhattacharyya, Ashoka Mahapatra, Tapas Kumar Som, Rashmi Ranjan Das, Swagata Tripathy, Tushar Subhadarshan Mishra, Anupam Dey, Vandana Kalwaje Eshwara, Muralidhar Varma, Balram Ji Omar, Ankit Aggarwal, Sherish Baqal, Langpoklakpam Chaoba Singh, Neeraj Gupta, Pradeep Bhatia, Kuldeep Singh, Daisy Khera, D Himanshu, Sarika Gupta, Zia Arshad, Ullash Bhabhor, Rahul Sarode, Satyajit Pradhan, Manisha Subrao Mane, Shalini Dewan Duggal, Rajender Kumar, GP Kaushal, Vikas Dabas, Aparna Ningombam, Subodh Kumar, Kapil Dev Soni, Sushma Sagar, Richa Aggarwal, Deepak Gupta, Gyaninder Pal Singh, Ashish Bindra, Kamran Farooque, Parin Lalwani, Kamini Walia · 发表于：The Lancet Global Health · 年份：2025 · DOI：10.1016/s2214-109x(25)00221-9 · 被引用次数：9 · 研究领域：Central Venous Catheters and Hemodialysis、Nosocomial Infections in ICU、Surgical site infection prevention

BACKGROUND: Central line-associated bloodstream infections (CLABSIs) are preventable health-care-associated infections (HAIs) that cause considerable morbidity and mortality. Understanding the epidemiology of CLABSIs through large, quality-assured, hospital-based datasets could help to enable development of preventive protocols suited to specific health-care systems. We aimed to describe the profile of CLABSIs in intensive care units (ICUs) at tertiary care centres in India. METHODS: We obtained data from around 200 adult, paediatric, and neonatal ICUs at 54 hospitals reporting to the Indian HAI surveillance network over a period of 7 years. All hospitals conducted bloodstream infection surveillance using standardised protocols. Cases of CLABSI were recorded on standard case report forms and were submitted to the HAI surveillance database. Denominator data (patient-days and central line-days) were entered monthly. Data quality was evaluated by a central team at the All-India Institute of Medical Sciences (New Delhi, India). We calculated CLABSI rates per 1000 central line-days and central-line utilisation ratio (CLUR) by year and ICU type (adult, paediatric, or neonatal). Commonly reported pathogens were ranked and the proportions of priority pathogens showing antimicrobial resistance were also estimated for each 1-year period and each ICU type. FINDINGS: During the surveillance period from May 1, 2017 to April 30, 2024, 8629 laboratory-confirmed CLABSI events, 3 054 124 pati...