Mesaconic acid as a key metabolite with anti-inflammatory and anti-aging properties produced by Lactobacillus plantarum 124 from centenarian gut microbiota

作者：Lei Wu, Hongxin He, Tingting Liang, Gaoming Du, Longyan Li, Haojie Zhong, Ying Li, J. W. Zhang, Ning Chen, Tong Jiang, Juan Yang, Jiangyan Wang, Shuo Feng, Shenghua Lu, Hui Zhao, Qihui Gu, He Gao, Guanghui Li, Wen-Rui Xie, Li‐Hao Wu, Qingping Wu, Xinqiang Xie, Xing‐Xiang He · 发表于：npj Biofilms and Microbiomes · 年份：2025 · DOI：10.1038/s41522-025-00812-9 · 被引用次数：11 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Microbial Metabolites in Food Biotechnology

The gut microbiota of centenarians plays a vital role in promoting healthy longevity. We performed a cross-sectional study of 224 people from Jiaoling, China, which is globally recognised for the longevity of its residents. Compared with younger people, centenarians showed significantly increased alpha-diversity, enrichment of the beneficial bacteria Lactobacillus, Akkermansia, and Christensenella, and increased redox capacity in the gut microbiota. Serum metabolomics of centenarians showed significant enrichment of antioxidant metabolites, including L-ascorbic acid 2-sulphate and lipoic acid. Finally, we isolated and screened a strain of Lactobacillus plantarum 124 (LP124) with a good antioxidant effect on the gut microbiota of centenarians. Animal experiments further verified that mesaconic acid from LP124 regulates the gut microbiota, is anti-inflammatory, relieves oxidative stress, maintains the intestinal barrier, and is the best-known anti-aging molecule. LP124 derived from the gut microbiota of centenarians and its metabolite mesaconic acid, have a significant positive effect on health and longevity.