Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy

作者：Yong-Bo Lv, Dashuai Zhu, Junlang Li, Yuan Li, Chao Lü, Jianing Bi, Ke Huang, Shiqi Hu, Shuo Liu, Na Yan, Ke Cheng, Juan Wang · 发表于：Nature Communications · 年份：2025 · DOI：10.1038/s41467-025-62020-5 · 被引用次数：14 · 研究领域：Coenzyme Q10 studies and effects、Electrospun Nanofibers in Biomedical Applications、Tissue Engineering and Regenerative Medicine

Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component therapeutic system from different parts of Glycyrrhiza: a functional hydrogel made from glycyrrhizic acid extracted from the stem and root, and nanosized chloroplast units (NCUs) derived from leaves. The hydrogel demonstrates therapeutic effects during both hypoxia and reoxygenation stages in vitro, while the photosynthetic NCUs alleviate hypoxia injury by providing ATP and NADPH under illumination. Subsequent in vivo study reveals the most significant therapeutic effect in the combination group (NCU plus hydrogel), which effectively treats both ischemic and reperfusion stages. Our study highlights the cross-species application of plant photosynthetic mechanisms in MI treatment and confirms that simultaneous treatment of ischemia and reperfusion is more effective than treating either stage alone, offering a promising therapeutic strategy for MI. Ischemic injury and reperfusion injury collectively determine total infarct size, a major prognostic factor, following myocardial infarction (MI). Here, Lv et al. develop a hydrogel system utilizing different parts of Glycyrrhiza and apply plant-based photosynthetic mechanisms to treat both ischemic and reperfusion inj...