Role of 18 F‐florzolotau PET in diagnostic and therapeutic decision‐making for cognitive impairment

作者：Jun Wang, Ziyi Wang, Shufen Chen, Rongze Wang, Ke‐Liang Chen, Jiaying Lu, Jiawei Xin, Yuyuan Huang, Mingyu Wang, Fang Xie, Wei Cheng, Tzu‐Chen Yen, Claude M. Wischik, Mei Cui, Chuantao Zuo, Qianhua Zhao, Yan‐Jiang Wang, Jin‐Tai Yu · 发表于：Alzheimer s & Dementia · 年份：2025 · DOI：10.1002/alz.70563 · 被引用次数：2 · 研究领域：Alzheimer's disease research and treatments、Parkinson's Disease Mechanisms and Treatments、Medical Imaging Techniques and Applications

Abstract INTRODUCTION The novel positron emission tomography (PET) tracer, 18 F‐florzolotau, enables in vivo visualization of tau pathology. METHODS We evaluated the diagnostic performance of disease‐specific spatial patterns of 18 F‐florzolotau PET imaging by visual read for tauopathies and its added value in diagnostic and therapeutic decision‐making in 1277 participants with cognitive complaints. RESULTS The disease‐specific spatial patterns of 18 F‐florzolotau PET imaging demonstrated high diagnostic accuracy in differentiating various tauopathies, with 96.0% for Alzheimer's disease, 94.4% for frontotemporal lobe degeneration, 93.7% for progressive supranuclear palsy, and 97.5% for corticobasal degeneration. Added to a standard diagnostic workup, 18 F‐florzolotau PET reading led to diagnostic revisions for 247 participants (19.3%), increased diagnostic confidence from 68.6% to 81.3%, and resulted in medication changes for 284 participants (22.2%). DISCUSSION Our data advocate for the strategic implementation of 18 F‐florzolotau PET in memory clinics, offering transformative potential for patient care and management. Highlights 18 F‐Florzolotau PET imaging presented disease‐specific spatial patterns for different tauopathies. The disease‐specific spatial patterns of 18 F‐florzolotau positron emission tomography (PET) imaging exhibited high diagnostic accuracy in differentiating various tauopathies. Integration of 18 F‐florzolotau PET imaging modality to a standard diagnost...