Brain Abnormalities in Children Exposed Prenatally to the Pesticide Chlorpyrifos

作者：Bradley S. Peterson, Sahar Delavari, Ravi Bansal, Siddhant Sawardekar, Chaitanya Gupte, Howard Andrews, Lori Hoepner, Wanda Garcia, Frederica P. Perera, Virginia Rauh · 发表于：JAMA Neurology · 年份：2025 · DOI：10.1001/jamaneurol.2025.2818 · 被引用次数：15 · 研究领域：Pesticide Exposure and Toxicity、Pesticide and Herbicide Environmental Studies、Toxic Organic Pollutants Impact

Importance: Chlorpyrifos (CPF) is one of the most widely used insecticides throughout the world. Preclinical and clinical studies have suggested that prenatal CPF exposure is neurotoxic, but its effects on the human brain are unknown. Objective: To identify the associations of prenatal CPF exposure with brain structure, function, and metabolism in school-aged children. Design, Setting, and Participants: This prospective, longitudinal pregnancy cohort study was conducted from January 1998 to July 2015, with data analysis from February 2018 to November 2024 in a community in northern Manhattan and South Bronx, New York. Of 727 pregnant women of African American or Dominican descent in the original community cohort, 512 had CPF levels measured at delivery. Offspring 6 years and older were approached for magnetic resonance imaging (MRI) scanning. Exposure: Prenatal CPF exposure. Main Outcomes and Measures: Anatomical MRI measures of cortical thickness and local white matter volumes, diffusion tensor imaging indices of tissue microstructure, MR spectroscopy indices of neuronal density, arterial spin labeling measures of regional cerebral blood flow, and cognitive performance measures. Prespecified hypotheses before data collection included CPF-related structural abnormalities in frontotemporal cortices, basal ganglia, and white matter pathways interconnecting them, and reduced neuronal density. Results: Participants included 270 youths (123 boys and 147 girls) aged 6.0 to 14.7 yea...