SOX9: an important factor in regulating breast cancer

作者：Yaru Wang, Juhang Chu, Luyao Huang, Mingping Qian · 发表于：European journal of medical research · 年份：2025 · DOI：10.1186/s40001-025-02730-0 · 被引用次数：3 · 研究领域：RNA Research and Splicing、Cancer Cells and Metastasis、Estrogen and related hormone effects

The SRY-Box Transcription Factor 9 (SOX9) is a crucial transcription factor that controls the growth, differentiation, and stemness of progenitor cells. According to research, SOX9 protein controls the initiation and progression of tumors by directly participating in tumor initiation, proliferation, migration, and chemotherapy resistance. Although SOX9 overexpression is frequently found in breast cancer, the precise molecular mechanism is yet unknown. This article reviews the structure, function, and new developments of SOX9 in the pathogenesis and treatment of breast cancer, and proposes that targeting SOX9 may improve the therapeutic effect of breast cancer and provide a reference for clinical work.