Research Progress of Platinum-Based Complexes in Lung Cancer Treatment: Mechanisms, Applications, and Challenges

作者：Wanqi Liang, Yufeng Huang, Yi Wang, Desheng Lu, Qi Sun · 发表于：International Journal of Molecular Sciences · 年份：2025 · DOI：10.3390/ijms26167958 · 被引用次数：8 · 研究领域：Metal complexes synthesis and properties、Ferrocene Chemistry and Applications、Synthesis and Biological Evaluation

Platinum-based complexes, as one of the mainstay chemotherapeutic agents in oncology, have evolved from first-generation Cisplatin to third-generation Oxaliplatin, with numerous platinum complexes currently under clinical investigation. This review systematically evaluates all existing platinum complexes for lung cancer treatment, including three generations of approved agents and investigational candidates, with comprehensive analysis of therapeutic efficacy and toxicity profiles. Our assessment aims to provide novel insights for developing next-generation platinum complexes with optimal therapeutic potential.