Developing biobanking processes for Alzheimer's disease and related dementia research in Africa: Experience from the Recruitment and Retention for Alzheimer's Disease Diversity in the Alzheimer's Disease Sequencing Project (READD‐ADSP)

作者：Kazeem Sanjo Akinwande, Patrice Whitehead, Samuel Diala, Motunrayo Coker, Larry D. Adams, Mayowa Ogunronbi, Olayemi Balogun, Richard Boateng, William Kudzi, Ajibola Tunde Falayi, Pascalyne Nyamai, Célia Novela, Tsehayneh Kelemu, Jimoh Abdulraheem, Osimhiarherhuo Adeleye, Roosevelt Anyanwu, Jedidiah Ankamah, Bamigbowu Olugbenga Emmanuel, Lucius Chidiebere Imoh, Wonder Agudey Doku‐Agama, Happiness Kumburu, Rogers Kamulegeya, Komolafe Benjamin Ige, O. O. Famuyiwa, Gabriel Ogunde, Faith Chinaza Ejimkonye, Joshua Akinyemi, Mike Cuccaro, Pedro Mena, Godwin Ogbole, Olufisayo Elugbadebo, Temitope Farombi, Michelle Nichols, Sunday Adeniyi, Muhammed Mubashir B Uthman, Christine Musyimi, Victoria Mutiso, Kolawole Wahab, Godwin Osaigbovo, Ernest Nwazor, Nosakhare Osemwegie, Paul Nwani, Adefolakemi Temitope Ogundele, Paul Olowoyo, Emmanuel Iwuozo, Damas Andrea, Reginald Obiako, Fred Stephen Sarfo, Albert Akpalu, Thierry Adoukonou, Biniyam A. Ayele, Yared Zenebe, Kamada Lwere, Albertino Damasceno, Alfred K. Njamnshi, Judith Boshe, Stella‐Maria Paddick, Sudha Seshadri, Jacob L. McCauley, Richard Walker, Oyedunni Arulogun, Njideka Okubadejo, Olusegun Baiyewu, Goldie S. Byrd, Mayowa Owolabi, David M. Ndetei, Brian W. Kunkle, Anthony J. Griswold, Raj N. Kalaria, Jeffery M. Vance, Adesola Ogunniyi, Margaret A. Pericak‐Vance, Rufus Akinyemi · 发表于：Alzheimer s & Dementia · 年份：2025 · DOI：10.1002/alz.70559 · 被引用次数：4 · 研究领域：Genomics and Rare Diseases、Health Systems, Economic Evaluations, Quality of Life、Ethics in Clinical Research

The Recruitment and Retention for Alzheimer's Disease Diversity in the Alzheimer's Disease Sequencing Project (READD-ADSP) aims to recruit 5000 African participants (Alzheimer's disease [AD] and cognitively unimpaired controls) to generate genomic and biomarker data to better characterize AD neurobiology in Africa from countries that constitute the African Dementia Consortium (AfDC). Blood samples from study participants are separated into fractions and transported to the African Coordinating Centre (ACC: Ibadan, Nigeria), where DNA extraction and long-term biospecimen storage are carried out. Plasma and DNA aliquots are shipped to the John P. Hussman Institute for Human Genomics, University of Miami (HIHG-UM, Miami, USA) for genotyping, whole genome sequencing, and biomarker analysis. Innovative solutions were devised to mitigate challenges encountered so far. Our biobanking experience in a low-resource setting demonstrates the feasibility of establishing a successful African biobanking network, as an important infrastructure to support Alzheimer's disease and related dementias research in Africa. HIGHLIGHTS: Biobanking is gaining grounds in Africa in studies related to neurological disorders. The Recruitment and Retention for Alzheimer's Disease Diversity in the Alzheimer's Disease Sequencing Project (READD-ADSP) biobanking network is a new initiative to enhance infrastructure for Alzheimer's disease and related dementias (ADRD) research in Africa through the African Dement...