Changes in lung function in children after pneumonia: a multicenter study

作者：Hejun Jiang, Jingsheng Dai, Guifang Zhou, Guijun Yang, Liwen Zhang, Shuhua Yuan, Jing Zhang, Jiande Chen, Mingyu Tang, Jilei Lin, Li Li, Yufen Wu, Yong Yin · 发表于：˜The œItalian Journal of Pediatrics/Italian journal of pediatrics · 年份：2025 · DOI：10.1186/s13052-025-02092-7 · 被引用次数：2 · 研究领域：Pneumonia and Respiratory Infections、Respiratory viral infections research、Pediatric health and respiratory diseases

BACKGROUND: There are few studies on the changes in lung function after pneumonia in children. This study aims to explore the changes in lung function in children after pneumonia and analyze the risk factors for airway disorder, especially the impact of different pathogen infection on lung function. METHODS: This study collected data from patients who were hospitalized due to pneumonia in ten Chinese hospitals between January 2023 and December 2024. Pulmonary function tests were performed to assess changes in lung function one week and one month after discharge. RESULTS: A total of 566 children were included in this study, with 40.6% of patients still showing airway disorder one week after discharge. Different pathogenic infections had varying effects on pulmonary function. MP (Mycoplasma pneumoniae) infection [OR (95%CI): 1.881(1.268-2.789), P = 0.001] and RhV (rhinovirus) infection [OR (95%CI): 2.402(1.027-5.621), P = 0.043] were significant risk factors for the occurrence of SAD (Small Airway Disorder) one week after discharge. Male gender [OR (95%CI): 2.219, P = 0.001] and MP infection [OR (95%CI): 1.681(1.024-2.761), P = 0.039] were significant risk factors for the occurrence of LAD (Large Airway Disorder) one week after discharge. No positive pathogen results [OR (95%CI): 0.366(0.168-0.800), P = 0.011] were significant protective factors for the persistence of SAD one month after discharge, while RhV infection [OR (95%CI): 7.286(0.802, 66.238), P = 0.077] and lung conso...