Oxytocin, Vasopressin and Stress: A Hormetic Perspective

作者：Hans P. Nazarloo, Marcy A. Kingsbury, Hannah Lamont, Caitlin V. Dale, Parmida Nazarloo, John M. Davis, Eric C. Porges, Steven P. Cuffe, C Sue Carter · 发表于：Current Issues in Molecular Biology · 年份：2025 · DOI：10.3390/cimb47080632 · 被引用次数：12 · 研究领域：Neuroendocrine regulation and behavior、Stress Responses and Cortisol、Circadian rhythm and melatonin

The purpose of this article is to examine a previously unrecognized role for the vasopressin-oxytocin (VP-OT) system in mammalian "stress-response hormesis." The current review adds hormesis to the long list of beneficial effects of OT. Hormesis, a biphasic adaptive response to low-level stressors, is introduced here to contextualize the dynamic roles of oxytocin and vasopressin. As with hormesis, the properties of the VP-OT system are context-, time-, and dose-sensitive. Here we suggest that one key to understanding hormesis is the fact that VP and OT and their receptors function as an integrated system. The VP-OT system is capable of changing and adapting to challenges over time, including challenges necessary for survival, reproduction and sociality. Prior research suggests that many beneficial effects of OT are most apparent only following stressful experiences, possibly reflecting interactions with VP, its receptors and other components of the hypothalamic-pituitary-adrenal axis. The release of OT is documented following various kinds of hormetic experiences such as birth, vigorous exercise, ischemic events and the ingestion of emetics, including psychedelics. The phasic or cyclic modulation of VP and related "stress" hormones, accompanied or followed by the release of OT, creates conditions that conform to the core principles of hormesis. This concept is reviewed here in the context of other hormones including corticotropin releasing hormone (CRH) and urocortin, as well...