Discovery of a novel tetrapeptide as glucose homeostasis modulator with bifunctionalities of targeting DPP‐IV and microbiota

作者：Haihong Chen, Wei Li, Weiguo Hu, Junyu Liu, Canyang Zhang, Yi Wang, Chong Zhang, Xizhen Zhang, Shuo Chen, Qixing Nie, Xin‐Hui Xing · 发表于：iMeta · 年份：2025 · DOI：10.1002/imt2.70072 · 被引用次数：12 · 研究领域：Diabetes Treatment and Management、Diet, Metabolism, and Disease、Natural Antidiabetic Agents Studies

AI-driven and computation-based high-throughput methods were developed to mine novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from hemp seed proteins. The identified peptide VAMP demonstrates a glucose-lowering effect through dual mechanisms: inhibition of DPP-IV activity and selective promotion of intestinal Akkermansia muciniphila growth.