Machine learning-guided engineering of chalcone synthase enables high-selectivity phloretin biosynthesis in yeast

作者：Minyong Li, Canyu Zhang, Hui Liang, Boyu Wu, Wenxi Yu, Guangjian Li, Yufei Cao, Wen‐Yong Lou · 发表于：Green Chemistry · 年份：2025 · DOI：10.1039/d5gc03435c · 被引用次数：12 · 研究领域：Plant Gene Expression Analysis、Plant biochemistry and biosynthesis、Plant-Microbe Interactions and Immunity

Machine learning-guided engineering of chalcone synthase effectively overcomes substrate promiscuity, enabling highly selective biosynthesis of phloretin in yeast, and provides a framework for the microbial production of high-value natural products.