Predictive value of acute neuroplastic response to taVNS in treatment outcome in persistent abdominal pain: A concurrent taVNS-EEG trial

作者：Suping Cai, Qihan Li, Lina Liu, Qingchuan Zhao, Qinxian Huang, Kai Yuan · 发表于：Brain stimulation · 年份：2025 · DOI：10.1016/j.brs.2025.08.009 · 被引用次数：8 · 研究领域：Anesthesia and Neurotoxicity Research、Cardiac, Anesthesia and Surgical Outcomes、Cardiovascular Syncope and Autonomic Disorders

Persistent abdominal pain (PAP)—defined as chronic pain lasting more than six months with refractory to conventional treatments—poses a substantial clinical challenge [1]. Non-invasive neuromodulation approaches, such as transcutaneous auricular vagus nerve stimulation (taVNS), have thus gained traction as potential alternatives by targeting maladaptive neuroplasticity within pain-processing pathways [2]. The therapeutic effects of taVNS are attributed to its capacity to enhance neuroplasticity in brain regions that regulate pain perception [3].