Differentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes

作者：David Parker, Rebekah Trotti, Jennifer E. McDowell, Sarah Keedy, Matcheri S. Keshavan, Godfrey D. Pearlson, Elliot S. Gershon, Elena I. Ivleva, Ling-Yu Huang, Kodiak Sauer, S. Kristian Hill, John A. Sweeney, Carol A. Tamminga, Brett A. Clementz · 发表于：Translational Psychiatry · 年份：2025 · DOI：10.1038/s41398-025-03501-5 · 被引用次数：6 · 研究领域：Functional Brain Connectivity Studies、Schizophrenia research and treatment、Obsessive-Compulsive Spectrum Disorders

Idiopathic psychosis shows considerable biological heterogeneity across cases. The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) used psychosis-relevant biomarkers to identify psychosis Biotypes, which will aid etiological and targeted treatment investigations. Here, our previous approach (Clementz et al. 2022) is updated, which supports the development of an efficient psychosis Biotype diagnostic procedure called ADEPT. Psychosis probands (n = 1907), their first-degree biological relatives (n = 705), and healthy participants (n = 895) completed a biomarker battery composed of cognitive performance, saccades, and auditory EEG/ERP measurements. EEG and ERP quantifications were modified from previous Biotypes iterations. Multivariate integration using multiple approaches reduced biomarker outcomes to 11 "bio-factors." Twenty-four different approaches indicated bio-factor data among probands were best described by three subgroups. Numerical taxonomy with k-means clustering yielded psychosis Biotypes; Rand Indices evaluated individual-case consistency of Biotype assignments. Psychosis subgroups, their non-psychotic first-degree relatives, and healthy individuals were compared across bio-factors. The three psychosis Biotypes differed significantly on all 11 bio-factors, especially prominent for general cognition, antisaccades, ERP magnitude, and intrinsic neural activity. Rand Indices showed excellent individual-case consistency of Biotype membership when samp...