Safety of having a subsequent pregnancy after prior diagnosis of breast cancer during pregnancy in young BRCA carriers

作者：Massimo Perachino, Eva Blondeaux, Virginia Delucchi, Rinat Bernstein‐Molho, Sophie Frank, Shani Paluch–Shimon, Sabine C. Linn, Antonio Di Meglio, Fedro Alessandro Peccatori, H C F Moore, Anastassia Parokonnaya, Thomas M. Renaud, Kenny A. Rodriguez‐Wallberg, Ann H. Partridge, Katarzyna Pogoda, Alberta Ferrari, Hans P. M. W. Wildiers, Angela Toss, Christine Rousset‐Jablonski, Hyo Jung Kim, María Florencia Varela, Octavi Córdoba, Cristina Damian, Maximilian Marhold, Alessandra Fabi, Stephanie L. Graff, A. Rodriguez-Hernandez, Maiko Okano, Renata Duchnowska, Helena Luna Pais, Roberta Di Rocco, Hatem A. Azim, Elene Mariamidze, Hampig Raphaël Kourié, Luca Arecco, Estela Carrasco, Elisa Agostinetto, Judith Balmañà, Cristina Saura, Matteo Lambertini · 发表于：ESMO Open · 年份：2025 · DOI：10.1016/j.esmoop.2025.105513 · 被引用次数：7 · 研究领域：Cancer Risks and Factors、Reproductive Biology and Fertility、BRCA gene mutations in cancer

BACKGROUND: For women carrying a germline pathogenic or likely pathogenic variant in the BRCA1/2 genes, having a pregnancy following breast cancer diagnosis and treatment is safe. However, no evidence exists on the safety of having a subsequent pregnancy in BRCA carriers with a prior diagnosis of breast cancer during pregnancy (PrBC). METHODS: The BRCA BCY Collaboration (NCT03673306) is an international, multicenter, retrospective cohort study that included BRCA carriers diagnosed with invasive breast cancer at the age ≤40 years between January 2000 and December 2020. This analysis included only women diagnosed with PrBC comparing patients who had a subsequent pregnancy to those without. Primary endpoints were the cumulative incidence of having a subsequent pregnancy and disease-free survival (DFS). Secondary endpoints were overall survival, pattern of first DFS events and reproductive outcomes. RESULTS: Of 6238 BRCA carriers from 109 centers worldwide, 282 patients with PrBC were included in this analysis, of whom 68 had a subsequent pregnancy and 214 did not. The 10-year cumulative incidence of having a subsequent pregnancy was 36.6% [95% confidence interval (CI) 29.5% to 44.8%]. Patients with a subsequent pregnancy were more likely to be younger at diagnosis (median age 31 years versus 34 years) and to have triple-negative tumors (73.5% versus 55.1%). Among patients with a subsequent pregnancy, median time from diagnosis to conception was 3.3 years (interquartile range 2.0...