Predictive Role of Fixation Stability for Clinical Stages and Conversion in Schizophrenia and Its Correlation with Cognitive Function

作者：Yuqing Gu, Yu Li, Lihua Xu, Tianhong Zhang, HuiRu Cui, YanYan Wei, Mengqing Xia, Wenjun Su, Yingying Tang, XiaoChen Tang, Dan Zhang, Xu Liu, Jijun Wang · 发表于：Schizophrenia Bulletin · 年份：2025 · DOI：10.1093/schbul/sbaf132 · 被引用次数：2 · 研究领域：Schizophrenia research and treatment、Memory and Neural Mechanisms、Tryptophan and brain disorders

BACKGROUND AND HYPOTHESIS: Given that fixation stability is closely linked to cognition, we investigated fixation stability in patients at different stages of schizophrenia, its relationship with cognitive impairments, and its predictive role for conversion to psychosis. STUDY DESIGN: Fixation stability was measured by bivariate contour ellipse area (BCEA), and cognition was assessed by the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery for 75 patients with first-episode schizophrenia (FES), 75 patients with clinical high-risk (CHR) syndrome, and 75 healthy controls (HCs). After a 1-year longitudinal study, CHR follow-up outcomes were classified as CHR-converters and CHR-nonconverters. Diagnostic model for clinical stages and prediction model for conversion were constructed using logistic regression and Cox regression, respectively. STUDY RESULTS: Patients exhibited fixation instability and cognition impairments compared to HC, with impairments increasing from CHR to FES. In CHR, BCEA negatively correlated with Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery scores, but this correlation was absent in FES. Diagnostic model effectively discriminated HC and FES, with an area under the receiver-operating characteristic curve of 0.914. Among 66 CHR followed up for 1 year, 13 have converted to schizophrenia, with a conversion rate of 19.70%. When divided into large and small B...