Remote ischaemic conditioning improves outcomes of ischaemic stroke treated by endovascular thrombectomy: the SERIC-EVT trial

作者：Zhen‐Ni Guo, Reziya Abuduxukuer, Chao Wang, Yang Qu, Peng Zhang, Junfeng Zhao, Xuefeng Hu, Dongsheng Ju, Tao Hao, Changming Wen, Yifeng Liu, Yang Zhou, Hongyu Li, Jiangang Zhang, Zhi-Mei Yuan, Jie Min, Xixi Qiu, Z. Li, Yan Jia, Wenbo Zhang, Xiao‐Guang Song, Jian-Xin Xu, Dawei Chen, Jinli Zhang, Liping Wang, Hong-Jian Guan, Xiaolin Tan, Peng Jiang, Yanli Zhao, Zhenjiang Yu, Hang Jin, Xin Sun, Duolao Wang, Thanh N Nguyen, Yi Yang, SERIC-EVT Study Group, Guan-Hua Ding, Jiangang Zhang, Kun Wu, Ruiming Li, W. Xie, Zhenhua Li, Zheng‐Yang Wang, Huiping Zhang, Min Zhang, Tao Hao, Ting Zhang, Xian-Hua Hao, Xiangning Zhang, Ya‐Nan Yang, Yan-Yan Pan, Yunbing Liu, Yuan Qu, Zhiyu Qiao, Bin-Liao Zhang, Dandan He, Dandan Liu, Guang Yang, Guangyi Li, Hong-Xue Cheng, Liu-Xia Gan, Luyao Wang, Peipei Qin, Qiao-Hong Gao, Ranran Xin, R. Feng, Shengyu Xu, Wan-Yu Zhao, Wenchao Lu, Xiaoxi Zhang, Xi-Xi Qiu, Yan-Yan Zhou, Yuan-Yuan Xing, Yuzhe Wang, Zhi-Duo Cai, Hui Li, Jinli Zhang, Jinfeng Li, Liang Liu, Peng-Cheng Dong, Zhi-Dan Li, Hui-Ling Qu, Hui-Sheng Chen, Liang Liu, Mingrui Chen, Tianyi Zheng, Weijun Hao, Xian‐Hui Sun, Xiaolong Li, Xiaoyu Sun, Xin Liu, Yihan Wang, Yonggang Zhao, Zi‐Ai Zhao, Zi‐Yang Shang, Hongyu Li, Hongyu Wang, Jing Ma, Yu-Hang Sang, Fangfang Liu, Si-Yin Sun, Xiuping Liu, Xue-Feng Hu, Lixiang Wang, Wenxin Jia, Yi Xia, Xianjun Qi, Xuemei Zhou, Zhenjiang Yu, Cui Wang, Dan Xu, Fu-Jin Li, Liyan Liu, Shuang Yu, Wenbo Zhang, Wenjuan Ma, Wen-Tong Song, Yan Jia, Бо Лі, D.-S. Zhang, Fei-Meng Kong, Fengxia Wang, Ge Feng, Haojie Sun, Hao-Rui Guo, Hongwei Lu, Jia-Ran Wang, Liping Wang, Lintao Ma, Qi Wang, Xiaoyang Zhang, Yan-Jie Wang, Yuan-Yuan Li, Hao Qiu, Haolong Qi, Jie-Ting Wang, Sun Jun-na, Yang Zhou, Yao Lu, Changming Wen, Di Chen, Dong-Huan Zhang, Gaoqi Zhang, Jun Gao, Junwei Sun, Lei Wang, Ning Su, Rong-Yi Liu, Shuang Pei, Sarah Mia Shen-Lee Liu, Shi-Qian Guo, Shang Yang, Xiangxin Li, Xing-Cheng Qiu, Xudong Zhao, Yu Yang, Yi-Feng Liu, Yin-Xue Yang, Yongxin Guo, Yu Tian, Zaixing Zhang, Da-Wei Wang, Guohui Tang, Shangyu Wen, Wei Shao, Wenbo Zhang, Wenjuan Xia, De-Wang Pan, Junfeng Zhao, Yang Zheng, Zhiguo Zhang, Chao Han, Chunying Li, Dongsheng Ju, Jing Ma, Shi-Wei Pan, Yan-Hua Teng, Enbo Zhu, Guanghui Dong, Guang-Lin Jin, Guang-Lin Liu, Hong-Jian Guan, Lin-Zhuo Qu, Ming-Quan Lin, Min Zheng, Ming-Zhen Dong, Chao Wang, Jie Zhou, Meng-Lu Cong, Peng Zhang, Reziya Abuduxukuer, Wen-Jing Yin, Yang Qu, Yi Yang, Zhenni Guo, Ju‐Fang Liu, Juan Zhou, Lan Li, Lizhu Yang, Ping Li, Qin Huang, Wen-Juan Xiong, Yan Wu, Xiao-Lin Tan, Xu Zha, Yufeng Jiang, Xu Yan, Hang Hu, Jie Min, Rong Li, Yaya Wang, Yaofeng Hu, Luo Yi, Zhihua Wang, Guang-Hui Shi, Jian-Xin Xu, Jingwen Feng, Ke-Yu Qian, Qiang Chen, Jing Zhang, Nannan Song, Songwei Li, Li Yang, Zhi-Mei Yuan, Li-Fang Meng, Xiao‐Guang Song, Xiaoman Jiang, Yan He, Chang-Xin Dou, Ling-Dong Meng, Shao-Kuan Jiang, Zhenzhen Yao, Yanli Zhao, Huiyuan Wang, Peng Jiang, Weitao Yu, Xin-Zhao Jiang, Xu Wang · 发表于：European Heart Journal · 年份：2025 · DOI：10.1093/eurheartj/ehaf570 · 被引用次数：13 · 研究领域：Cardiac Ischemia and Reperfusion、Antiplatelet Therapy and Cardiovascular Diseases、Acute Ischemic Stroke Management

BACKGROUND AND AIMS: Even after endovascular thrombectomy, more than half of patients with acute large vessel occlusion stroke do not achieve favourable outcomes. This study aimed to assess the efficacy and safety of remote ischaemic conditioning (RIC), a promising neuroprotective treatment, in patients with acute ischaemic stroke who received endovascular thrombectomy. METHODS: This participant-blinded, randomized controlled clinical trial was conducted at 25 hospitals. Patients were randomized 1:1 to either the RIC (cuff pressure, 200 mmHg; twice daily for 7 days) or sham RIC (60 mmHg; same procedure) groups. The primary outcome was the proportion of patients with a modified Rankin Scale score of 0-2 on Day 90. The primary safety outcome was the proportion of patients with haemorrhagic transformation within 7 days. RESULTS: In total, 498 participants were recruited. Ten patients (2.0%) were excluded because they did not receive any intervention. Thus, 488 participants (244 in the RIC group and 244 in the sham RIC group) were included in the modified intention-to-treat analysis. At 90 days, 61.1% of the patients in the RIC group and 48.9% in the sham RIC group achieved a modified Rankin Scale score of 0-2 (unadjusted risk ratio 1.25, 95% confidence interval 1.06-1.47; P = .009). The proportion of patients with haemorrhagic transformation was 37.7% and 35.2% in the RIC and sham RIC groups, respectively. CONCLUSIONS: Among patients with acute ischaemic stroke who underwent end...