Effects of non-pharmacological interventions on cognitive function in patients with type 2 diabetes mellitus and mild cognitive impairment: A network meta-analysis

作者：Wei An, Dongqing Guo, Jie Wang, Xin Chu · 发表于：PLoS ONE · 年份：2025 · DOI：10.1371/journal.pone.0329397 · 被引用次数：3 · 研究领域：Dementia and Cognitive Impairment Research、Neurological Disorders and Treatments、Neurological Disease Mechanisms and Treatments

OBJECTIVE: Non-pharmacological intervention represents a significant therapeutic modality for the cognitive function intervention management of patients with type 2 diabetes accompanied by mild cognitive impairment. However, it remains unclear which intervention measure is the most effective. The objective of this study is to compare and rank the influences of various non-pharmacological interventions on the cognitive function of patients with type 2 diabetes and mild cognitive impairment. METHODS: Eight databases from the establishment of the database to November 2024 were retrieved. The quality of the literature was evaluated using the RoB2.0 tool. Paired Meta-analysis was conducted using Stata/SE 15.1 software, and Network Meta-analysis was performed using R 4.3.1 software. RESULTS: A total of 25 literatures were incorporated, encompassing 5 intervention measures, with a sample size of 2,446 cases. The results indicated that in the pairwise meta-analysis, when the MoCA score was used as the outcome indicator, cognitive training [MD = 2.3, 95% CI (1.64, 2.96), P < 0.01], exercise therapy [MD = 2.11, 95% CI (1.30, 2.92), P < 0.01], TCM therapy [MD = 2.28, 95% CI (0.76, 3.81), P < 0.01], and comprehensive intervention [MD = 1.98, 95% CI (1.53, 2.48), P < 0.01] were more effective in improving the cognitive status of patients than the control group; when the MMSE was used as the outcome indicator, cognitive training [MD = 2.03 95% CI (1.57, 2.49), P < 0.01], exercise therapy [...