Association of triglyceride-glucose-related indices with all-cause and cause-specific mortality in individuals with prediabetes

作者：Liwen Zhang, Weili Zhao, Panpan Zheng, Fang Huang, Lili Zhang, Yuxin Zhang, Xian Xiu, Pei Zhang, Zanchao Liu, Lipeng Liu · 发表于：Cardiovascular Diabetology · 年份：2025 · DOI：10.1186/s12933-025-02883-6 · 被引用次数：12 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Metabolism, Diabetes, and Cancer、Adipokines, Inflammation, and Metabolic Diseases

BACKGROUND: The triglyceride-glucose (TyG) index has been linked to the occurrence of prediabetes, but there is limited evidence regarding its association with mortality in individuals with prediabetes. Thus, this study aimed to explore the association between TyG-related indices and all-cause and cause-specific mortality in individuals with prediabetes. METHOD: Based on NHANES data from 1999 to 2018, the TyG index, TyG-waist circumference (TyG-WC), and TyG-waist-to-height ratio (TyG-WHtR) were calculated. Mortality data including all-cause mortality, cardiovascular disease (CVD) mortality, and cancer mortality were determined as of December 31, 2019. Kaplan-Meier curves, Cox regression analysis, and restricted cubic splines (RCS) were used to assess associations of TyG-related indices with all-cause and cause-specific mortality (CVD and cancer) in individuals with prediabetes. Subgroup and sensitivity analyses were used to confirm the robustness of the results. RESULTS: In total, 9,574 participants with prediabetes were included. Kaplan-Meier curves indicated that overall survival and cancer-specific survival were associated with different quartiles of the TyG index, with quartile 1 having the lowest all-cause mortality (P = 0.042 and P = 0.008). TyG-WHtR was negatively correlated with overall survival and CVD-specific survival (P < 0.001 and P = 0.012). Multivariate Cox regression analysis showed a significant positive correlation between the TyG index and cancer mortality ...